Stengaard, Carsten; Sørensen, Jacob T; Ladefoged, Søren A; Lassen, Jens F; Rasmussen, Martin B; Pedersen, Claus Kjær; Ayer, Antoine; Bøtker, Hans Erik; Terkelsen, Christian J; Thygesen, Kristian (2016). The potential of optimizing prehospital triage of patients with suspected acute myocardial infarction using high-sensitivity cardiac troponin T and copeptin. Biomarkers, 22(3-4), pp. 351-360. Taylor & Francis 10.1080/1354750X.2016.1265008
Full text not available from this repository. (Request a copy)PURPOSE
In patients with a suspected acute myocardial infarction (AMI), to evaluate the potential for early triage based on measurement of high-sensitivity cardiac troponin T (hs-cTnT) and copeptin in blood samples collected in the prehospital phase.
MATERIALS AND METHODS
In this retrospective study, we measured hs-cTnT and copeptin in blood samples collected in the ambulance form 962 patients with suspected AMI. The diagnostic accuracy was estimated by receiver-operating characteristic (ROC) curve area under the curve (AUC) for both biomarkers and a combined model. Multivariable Cox regression modelling was used to estimate the predictive value of both biomarkers.
RESULTS
In total, 178 (19%) cases had AMI. The AUC for hs-cTnT was 0.81. Adding copeptin increased the AUC to 0.85 (p = 0.004) and the combined model allowed a prehospital rule-out of 45% of cases without AMI (negative predictive value, NPV 98%). Both biomarkers are highly predictive of outcome.
CONCLUSIONS
A future application of hs-cTnT and copeptin measurement, performed already in the prehospital phase, could potentially improve the prehospital diagnostic and prognostic classification of patients with a suspected AMI.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology |
UniBE Contributor: |
Ayer, Antoine |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1366-5804 |
Publisher: |
Taylor & Francis |
Language: |
English |
Submitter: |
Antoine Ayer |
Date Deposited: |
30 Dec 2016 09:35 |
Last Modified: |
05 Dec 2022 15:00 |
Publisher DOI: |
10.1080/1354750X.2016.1265008 |
PubMed ID: |
27903076 |
Uncontrolled Keywords: |
Acute coronary syndrome; biomarkers; copeptin; diagnosis; prehospital emergency care; prognosis; troponin |
URI: |
https://boris.unibe.ch/id/eprint/92166 |
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