Influence of biphasic calcium phosphate surfaces coated with Enamel Matrix Derivative on vertical bone growth in an extra-oral rabbit model.

Wen, Bo; Li, Zhen; Nie, Rongrong; Liu, Chao; Zhang, Peng; Miron, Richard John; Dard, Michel M (2016). Influence of biphasic calcium phosphate surfaces coated with Enamel Matrix Derivative on vertical bone growth in an extra-oral rabbit model. Clinical oral implants research, 27(10), pp. 1297-1304. Wiley-Blackwell 10.1111/clr.12740

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OBJECTIVE The aim of this study was to investigate the ability of Enamel Matrix Derivative (EMD) on vertical bone regeneration around dental implants placed in an extra-oral rabbit model. MATERIAL AND METHODS A total of 30 Straumann BL implants were partially embedded in transverse orientation into the posterior mandibles of 15 rabbits. Macro-structuring BiPhasicCaPST (BCPT1), micro-structuring BiPhasicCaPST (BCPT2), and deproteinized bovine bone mineral (DBBM) were placed around the implant and covered with a scaffold stabilizing "umbrella." EMD was incorporated within the scaffold for test sites, but not control sites. Histological analysis was performed on retrieved specimens after 10 weeks of healing to assess new bone formation. RESULTS All treatment groups displayed new supracrestal bone formation as determined by histomorphometric measurements, with mean values of new bone height ranging between 0.62 and 1.13 mm. Histological analysis revealed a higher mean bone formation (%) around the test sites where EMD (34.7, 95%CI: 27.1-39.4) was released from the scaffold, whereas the control group without EMD release (26.4, 95%CI: 16.3-31.9) (P = 0.069). The mean fBIC (%) in the BCPT2 group increased by the addition of EMD relative to no EMD (67.2, 95%CI: 48.6-84.1) and (54.7, 95%CI: 32.3-68.9), respectively). The BCPT2/EMD and DBBM/EMD interventions showed the greatest mean bone density (BA/TA), respectively, (12.8, 95%CI: 8.9-36.5) and (11.2, 6.3-16.4) in ROI 1. Values in ROI 2 were, similarly, (24.9, 95%CI: 17.2-31.7) and (27.7, 19.2-35.3). BA/TA in ROI 2 differences between the BCPT2 groups with and without EMD was statistically significant (P = 0.026), as well as the DBBM groups with and without EMD (P = 0.038). CONCLUSIONS A layer of new bone was formed in both test and controls. The release of EMD from BCPT2 and DBBM adjacent to a bone-level implant with an SLActive surface and scaffold retention umbrella consistently regenerated the greater fBIC and bone density along the length of the implant.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > School of Dental Medicine, Periodontics Research
04 Faculty of Medicine > School of Dental Medicine > School of Dental Medicine, Oral Surgery Research

UniBE Contributor:

Miron, Richard John

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0905-7161

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Eveline Carmen Schuler

Date Deposited:

08 Mar 2017 11:10

Last Modified:

09 Sep 2017 18:29

Publisher DOI:

10.1111/clr.12740

PubMed ID:

26689728

Uncontrolled Keywords:

biphasic calcium phosphate materials; enamel matrix derivative; scaffold retainer; vertical supracrestal bone growth

BORIS DOI:

10.7892/boris.92185

URI:

https://boris.unibe.ch/id/eprint/92185

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