Differential Expression of Hox and Notch Genes in Larval and Adult Stages of Echinococcus granulosus

Dezaki, Ebrahim Saedi; Yaghoobi, Mohammad Mehdi; Taheri, Elham; Almani, Pooya Ghaseminejad; Tohidi, Farideh; Gottstein, Bruno; Harandi, Majid Fasihi (2016). Differential Expression of Hox and Notch Genes in Larval and Adult Stages of Echinococcus granulosus. Korean journal of parasitology, 54(5), pp. 653-658. Korean Society for Parasitology and Tropical Medicine 10.3347/kjp.2016.54.5.653

Preview

Text kjp-54-5-653.pdf - Published Version Available under License Creative Commons: Attribution-Noncommercial (CC-BY-NC). Download (913kB) | Preview

This investigation aimed to evaluate the differential expression of HoxB7 and notch genes in different developmental stages of Echinococcus granulosus sensu stricto. The expression of HoxB7 gene was observed at all developmental stages. Nevertheless, significant fold differences in the expression level was documented in the juvenile worm with 3 or more proglottids, the germinal layer from infected sheep, and the adult worm from an experimentally infected dog. The notch gene was expressed at all developmental stages of E. granulosus; however, the fold difference was significantly increased at the microcysts in monophasic culture medium and the germinal layer of infected sheep in comparison with other stages. The findings demonstrated that the 2 aforementioned genes evaluated in the present study were differentially expressed at different developmental stages of the parasite and may contribute to some important biological processes of E. granulosus.

Interest & Impact

Downloads

285 since deposited on 13 Mar 2017
22 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item