Differential Expression of Hox and Notch Genes in Larval and Adult Stages of Echinococcus granulosus

Dezaki, Ebrahim Saedi; Yaghoobi, Mohammad Mehdi; Taheri, Elham; Almani, Pooya Ghaseminejad; Tohidi, Farideh; Gottstein, Bruno; Harandi, Majid Fasihi (2016). Differential Expression of Hox and Notch Genes in Larval and Adult Stages of Echinococcus granulosus. Korean journal of parasitology, 54(5), pp. 653-658. Korean Society for Parasitology and Tropical Medicine 10.3347/kjp.2016.54.5.653

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This investigation aimed to evaluate the differential expression of HoxB7 and notch genes in different developmental stages of Echinococcus granulosus sensu stricto. The expression of HoxB7 gene was observed at all developmental stages. Nevertheless, significant fold differences in the expression level was documented in the juvenile worm with 3 or more proglottids, the germinal layer from infected sheep, and the adult worm from an experimentally infected dog. The notch gene was expressed at all developmental stages of E. granulosus; however, the fold difference was significantly increased at the microcysts in monophasic culture medium and the germinal layer of infected sheep in comparison with other stages. The findings demonstrated that the 2 aforementioned genes evaluated in the present study were differentially expressed at different developmental stages of the parasite and may contribute to some important biological processes of E. granulosus.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Parasitology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)

UniBE Contributor:

Gottstein, Bruno

Subjects:

600 Technology > 630 Agriculture
600 Technology > 610 Medicine & health

ISSN:

1738-0006

Publisher:

Korean Society for Parasitology and Tropical Medicine

Language:

English

Submitter:

Bruno Gottstein

Date Deposited:

13 Mar 2017 11:34

Last Modified:

13 Mar 2017 11:34

Publisher DOI:

10.3347/kjp.2016.54.5.653

PubMed ID:

27853123

Uncontrolled Keywords:

Echinococcus granulosus; HoxB7 gene; cystic echinococcosis; notch gene; real-time PCR

BORIS DOI:

10.7892/boris.92261

URI:

https://boris.unibe.ch/id/eprint/92261

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