Clinical benefit from resection of recurrent glioblastomas: results of a multicenter study including 503 patients with recurrent glioblastomas undergoing surgical resection.

Ringel, Florian; Pape, Haiko; Sabel, Michael; Krex, Dietmar; Bock, Hans Christoph; Misch, Martin; Weyerbrock, Astrid; Westermaier, Thomas; Senft, Christian; Schucht, Philippe; Meyer, Bernhard; Simon, Matthias (2016). Clinical benefit from resection of recurrent glioblastomas: results of a multicenter study including 503 patients with recurrent glioblastomas undergoing surgical resection. Neuro-Oncology, 18(1), pp. 96-104. Oxford University Press 10.1093/neuonc/nov145

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BACKGROUND While standards for the treatment of newly diagnosed glioblastomas exist, therapeutic regimens for tumor recurrence remain mostly individualized. The role of a surgical resection of recurrent glioblastomas remains largely unclear at present. This study aimed to assess the effect of repeated resection of recurrent glioblastomas on patient survival. METHODS In a multicenter retrospective-design study, patients with primary glioblastomas undergoing repeat resections for recurrent tumors were evaluated for factors affecting survival. Age, Karnofsky performance status (KPS), extent of resection (EOR), tumor location, and complications were assessed. RESULTS Five hundred and three patients (initially diagnosed between 2006 and 2010) undergoing resections for recurrent glioblastoma at 20 institutions were included in the study. The patients' median overall survival after initial diagnosis was 25.0 months and 11.9 months after first re-resection. The following parameters were found to influence survival significantly after first re-resection: preoperative and postoperative KPS, EOR of first re-resection, and chemotherapy after first re-resection. The rate of permanent new deficits after first re-resection was 8%. CONCLUSION The present study supports the view that surgical resections of recurrent glioblastomas may help to prolong patient survival at an acceptable complication rate.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery

UniBE Contributor:

Schucht, Philippe

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1523-5866

Publisher:

Oxford University Press

Language:

English

Submitter:

Nicole Söll

Date Deposited:

08 Mar 2017 12:40

Last Modified:

09 Sep 2017 18:42

Publisher DOI:

10.1093/neuonc/nov145

PubMed ID:

26243790

Uncontrolled Keywords:

glioblastoma; overall survival; recurrent tumor; surgical resection

BORIS DOI:

10.7892/boris.92283

URI:

https://boris.unibe.ch/id/eprint/92283

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