Combined thalamic and subthalamic deep brain stimulation for tremor-dominant Parkinson's disease.

Oertel, Markus Florian; Schüpbach, Michael; Ghika, Joseph-André; Stieglitz, Lennart H; Fiechter, Michael; Kaelin, Alain; Raabe, Andreas; Pollo, Claudio (2017). Combined thalamic and subthalamic deep brain stimulation for tremor-dominant Parkinson's disease. Acta neurochirurgica, 159(2), pp. 265-269. Springer 10.1007/s00701-016-3044-5

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Deep brain stimulation (DBS) in the thalamic ventral intermediate (Vim) or the subthalamic nucleus (STN) reportedly improves medication-refractory Parkinson's disease (PD) tremor. However, little is known about the potential synergic effects of combined Vim and STN DBS. We describe a 79-year-old man with medication-refractory tremor-dominant PD. Bilateral Vim DBS electrode implantation produced insufficient improvement. Therefore, the patient underwent additional unilateral left-sided STN DBS. Whereas Vim or STN stimulation alone led to partial improvement, persisting tremor resolution occurred after simultaneous stimulation. The combination of both targets may have a synergic effect and is an alternative option in suitable cases.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Oertel, Markus Florian; Schüpbach, Michael; Kaelin, Alain; Raabe, Andreas and Pollo, Claudio

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0001-6268

Publisher:

Springer

Language:

English

Submitter:

Nicole Söll

Date Deposited:

13 Jan 2017 17:00

Last Modified:

14 Sep 2017 15:50

Publisher DOI:

10.1007/s00701-016-3044-5

PubMed ID:

27966027

Uncontrolled Keywords:

Deep brain stimulation; Parkinson’s disease; Subthalamic nucleus; Thalamic ventral intermediate nucleus; Tremor

BORIS DOI:

10.7892/boris.92285

URI:

https://boris.unibe.ch/id/eprint/92285

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