Access to therapy and therapy outcomes in the Swiss Hepatitis C Cohort Study: a person-centred approach.

Giudici, F; Bertisch, B; Negro, F; Stirnimann, G; Müllhaupt, B; Moradpour, D; Cerny, A; Dufour, Jean-François; Keiser, O (2016). Access to therapy and therapy outcomes in the Swiss Hepatitis C Cohort Study: a person-centred approach. Journal of viral hepatitis, 23(9), pp. 697-707. Blackwell Science 10.1111/jvh.12535

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Socio-demographic and behavioural characteristics are associated with delayed diagnosis and disease progression in HCV-infected persons. However, many analyses focused on single variables rather than groups defined by several variables. We used latent class analysis to study all 4488 persons enrolled in the Swiss Hepatitis C Cohort Study. Groups were identified using predefined variables at enrolment. The number of groups was selected using the Bayesian information criterion. Mortality, loss to follow-up, cirrhosis, treatment status and response to antivirals were analysed using Laplace and logistic regressions. We identified five groups and named them according to their characteristics: persons who inject drugs, male drinkers, Swiss employees, foreign employees and retirees. Two groups did not conform to common assumptions about persons with chronic hepatitis C and were already in an advanced stage of the disease at enrolment: 'male drinkers' and 'retirees' had a high proportion of cirrhosis at enrolment (15% and 16% vs <10.3%), and the shortest time to death (adjusted median time 8.7 years and 8.8 years vs >9.0). 'Male drinkers' also had high substance use, but they were well educated and were likely to be employed. This analysis may help identifying high-risk groups which may benefit from targeted interventions.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)

UniBE Contributor:

Giudici, Fabio; Bertisch, Barbara; Stirnimann, Guido; Dufour, Jean-François and Keiser, Olivia


600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services




Blackwell Science




Doris Kopp Heim

Date Deposited:

30 Dec 2016 11:45

Last Modified:

21 Sep 2017 01:22

Publisher DOI:


PubMed ID:


Additional Information:

Giudici and Bertisch contributed equally to this work.

Uncontrolled Keywords:

Switzerland; alcohol; hepatitis C; latent class analysis; persons who inject drugs; socio-behaviour




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