Human Endogenous Retroviruses as Pathogenic Factors in the Development of Schizophrenia.

Slokar, Gorjan; Hasler, Gregor (2016). Human Endogenous Retroviruses as Pathogenic Factors in the Development of Schizophrenia. Frontiers in psychiatry, 6(183), p. 183. Frontiers 10.3389/fpsyt.2015.00183

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Schizophrenia is a complex disorder, characterized by the interplay between genetic and environmental factors. Human endogenous retroviruses (HERVs), genetic elements that originated from infections by exogenous retroviruses millions of years ago, comprise ~8% of the human genome. Here, we provide a comprehensive review of accumulating evidence, detailing HERV aberrancies associated with schizophrenia. Studies examining the genome, transcriptome, and proteome of individuals with schizophrenia provide data that support the association of these viral elements with the disorder. Molecular differences can be found within the central nervous system and peripheral tissues. However, additional studies are needed to substantiate the reported link and to address several discrepancies among previous investigations. We further discuss potentially relevant pathogenic mechanisms to the development of schizophrenia.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Healthcare Research

UniBE Contributor:

Hasler, Gregor

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1664-0640

Publisher:

Frontiers

Language:

English

Submitter:

Gregor Hasler

Date Deposited:

23 Feb 2017 13:03

Last Modified:

26 Feb 2017 02:11

Publisher DOI:

10.3389/fpsyt.2015.00183

PubMed ID:

26793126

Uncontrolled Keywords:

HERV-W; gene–environment interaction; human endogenous retrovirus; infectious; pathogenesis; schizophrenia

BORIS DOI:

10.7892/boris.92334

URI:

https://boris.unibe.ch/id/eprint/92334

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