Mlekusch, Sabine; Neziri, Alban Y.; Limacher, Andreas; Jüni, Peter; Arendt-Nielsen, Lars; Curatolo, Michele (2016). Conditioned Pain Modulation in Patients With Acute and Chronic Low Back Pain. The clinical journal of pain, 32(2), pp. 116-121. Lippincott Williams & Wilkins 10.1097/AJP.0000000000000238
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OBJECTIVES
Disturbed endogenous pain modulation is likely one of the mechanisms underlying central hypersensitivity and might be a contributing factor for the development and maintenance of chronic pain. To our knowledge, no study has investigated endogenous pain modulation in both acute and chronic low back pain (LBP). We tested the hypothesis that endogenous pain inhibition is impaired in patients with acute and chronic LBP.
MATERIALS AND METHODS
We evaluated 40 patients with acute LBP, 34 patients with chronic LBP and 30 pain-free controls for their conditioned pain modulation (CPM), with pressure pain tolerance and cold pressor as test and conditioning stimulus, respectively. Measurements were repeated up to 10 minutes after cold pressor test.
RESULTS
There was no difference in CPM among the groups immediately after cold pressor test. However, the decline in CPM effect was significantly faster in chronic and acute LBP patients than in controls, with no evidence for differences between pain groups.
DISCUSSION
The present study provides evidence for some alterations of endogenous modulation in both acute and chronic LBP. CPM was still detected in both patient groups, indicating that endogenous modulation, although effective for a shorter duration, is partially functioning in patients with LBP.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM) 04 Faculty of Medicine > Pre-clinic Human Medicine > Department of Clinical Research (DCR) 04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic and Policlinic for Anaesthesiology and Pain Therapy |
UniBE Contributor: |
Mlekusch, Sabine, Neziri, Alban Y., Limacher, Andreas, Jüni, Peter |
Subjects: |
600 Technology > 610 Medicine & health 300 Social sciences, sociology & anthropology > 360 Social problems & social services |
ISSN: |
0749-8047 |
Publisher: |
Lippincott Williams & Wilkins |
Language: |
English |
Submitter: |
Jeannie Wurz |
Date Deposited: |
03 Jan 2017 14:32 |
Last Modified: |
20 Feb 2024 14:17 |
Publisher DOI: |
10.1097/AJP.0000000000000238 |
PubMed ID: |
26741741 |
BORIS DOI: |
10.7892/boris.92385 |
URI: |
https://boris.unibe.ch/id/eprint/92385 |
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