Conditioned Pain Modulation in Patients With Acute and Chronic Low Back Pain.

Mlekusch, Sabine; Neziri, Alban Y.; Limacher, Andreas; Jüni, Peter; Arendt-Nielsen, Lars; Curatolo, Michele (2016). Conditioned Pain Modulation in Patients With Acute and Chronic Low Back Pain. The clinical journal of pain, 32(2), pp. 116-121. Lippincott Williams & Wilkins 10.1097/AJP.0000000000000238

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OBJECTIVES Disturbed endogenous pain modulation is likely one of the mechanisms underlying central hypersensitivity and might be a contributing factor for the development and maintenance of chronic pain. To our knowledge, no study has investigated endogenous pain modulation in both acute and chronic low back pain (LBP). We tested the hypothesis that endogenous pain inhibition is impaired in patients with acute and chronic LBP. MATERIALS AND METHODS We evaluated 40 patients with acute LBP, 34 patients with chronic LBP and 30 pain-free controls for their conditioned pain modulation (CPM), with pressure pain tolerance and cold pressor as test and conditioning stimulus, respectively. Measurements were repeated up to 10 minutes after cold pressor test. RESULTS There was no difference in CPM among the groups immediately after cold pressor test. However, the decline in CPM effect was significantly faster in chronic and acute LBP patients than in controls, with no evidence for differences between pain groups. DISCUSSION The present study provides evidence for some alterations of endogenous modulation in both acute and chronic LBP. CPM was still detected in both patient groups, indicating that endogenous modulation, although effective for a shorter duration, is partially functioning in patients with LBP.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine
04 Faculty of Medicine > Pre-clinic Human Medicine > CTU Bern
04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic and Policlinic for Anaesthesiology and Pain Therapy

UniBE Contributor:

Mlekusch, Sabine; Neziri, Alban Y.; Limacher, Andreas and Jüni, Peter

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

0749-8047

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Jeannie Wurz

Date Deposited:

03 Jan 2017 14:32

Last Modified:

23 Jan 2018 12:14

Publisher DOI:

10.1097/AJP.0000000000000238

PubMed ID:

26741741

BORIS DOI:

10.7892/boris.92385

URI:

https://boris.unibe.ch/id/eprint/92385

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