Mitochondrial protein import in trypanosomes: Expect the unexpected

Harsman, Anke Judith; Schneider, André (2017). Mitochondrial protein import in trypanosomes: Expect the unexpected. Traffic, 18(2), pp. 96-109. Wiley-Blackwell 10.1111/tra.12463

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Mitochondria have many different functions the most important one of which is oxidative phosphorylation. They originated from an endosymbiotic event between a bacterium and an archaeal host cell. It was the evolution of a protein import system that marks the boundary between the endosymbiotic ancestor of the mitochondrion and a true organelle that is under the control of the nucleus. In present day mitochondria more than 95% of all proteins are imported from the cytosol, in a process mediated by hetero-oligomeric protein complexes in the outer and inner mitochondrial membranes. In this review we compare mitochondrial protein import in the best studied model system yeast and the parasitic protozoan Trypanosoma brucei. The two organisms are phylogenetically only remotely related. Despite the fact that mitochondrial protein import has the same function in both species, only very few subunits of their import machineries are conserved. Moreover, while yeast has two inner membrane protein translocases, one specialized for presequence-containing and one for mitochondrial carrier proteins, T. brucei has a single inner membrane translocase only, that mediates import of both types of substrates. The evolutionary implications of these findings are discussed.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Departement of Chemistry and Biochemistry

UniBE Contributor:

Harsman, Anke Judith and Schneider, André

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry

ISSN:

1398-9219

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Christina Schüpbach

Date Deposited:

24 Jan 2017 10:06

Last Modified:

02 Feb 2017 09:47

Publisher DOI:

10.1111/tra.12463

PubMed ID:

27976830

BORIS DOI:

10.7892/boris.92439

URI:

https://boris.unibe.ch/id/eprint/92439

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