A systematic review of the outcomes reported in trials of medication review in older patients: the need for a core outcome set.

Beuscart, Jean-Baptiste; Pont, Lisa G; Thevelin, Stefanie; Boland, Benoit; Dalleur, Olivia; Rutjes, Anne; Westbrook, Johanna I; Spinewine, Anne (2017). A systematic review of the outcomes reported in trials of medication review in older patients: the need for a core outcome set. British journal of clinical pharmacology, 83(5), pp. 942-952. Wiley-Blackwell 10.1111/bcp.13197

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AIM Medication review has been advocated as one of the measures to tackle the challenge of polypharmacy in older patients, yet there is no consensus on how best to evaluate its efficacy. This study aimed to assess outcome reporting in trials of medication review in older patients. METHODS Randomized controlled trials (RCTs), prospective studies and RCT protocols involving medication review performed in patients aged 65 years or older in any setting of care were identified from: (1) a recent systematic review; (2) RCT registries of ongoing studies; (3) the Cochrane library. The type, definition, and frequency of all outcomes reported were extracted independently by two researchers. RESULTS 47 RCTs or prospective published studies and 32 RCT protocols were identified. A total of 327 distinct outcomes were identified in the 47 published studies. Merely one fifth (21%) of the studies evaluated the impact of medication reviews on adverse events like adverse drug reactions or drug-related hospital admissions. Most of the outcomes were related to medication use (n = 114, 35%) and healthcare use (n = 74, 23%). Very few outcomes were patient related outcomes (n = 24, 7%). A total of 248 distinct outcomes were identified in the 32 RCT protocols. Overall, the number of outcomes and the number and type of health domains covered by the outcomes varied largely. CONCLUSION Outcome reporting from RCTs concerning medication review in older patients is heterogeneous. This review highlights the need for a standardised core outcome set for medication review in older patients, to improve outcome reporting and evidence synthesis.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)
04 Faculty of Medicine > Pre-clinic Human Medicine > CTU Bern

UniBE Contributor:

Rutjes, Anne

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

0306-5251

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Doris Kopp Heim

Date Deposited:

05 Jan 2017 10:17

Last Modified:

28 Nov 2017 02:30

Publisher DOI:

10.1111/bcp.13197

PubMed ID:

27891666

Uncontrolled Keywords:

systematic review; medication review; randomized controlled trials; outcomes assessment; elderly

BORIS DOI:

10.7892/boris.92497

URI:

https://boris.unibe.ch/id/eprint/92497

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