Elucidation of the binding sites in antitumor metallocene - dinucleoside monophosphate adducts

Eberle, Rahel Patricia; Schürch, Stefan (27 October 2016). Elucidation of the binding sites in antitumor metallocene - dinucleoside monophosphate adducts (Unpublished). In: Meeting of the Swiss Group for Mass Spectrometry (SGMS). Beatenberg, Switzerland. 27.-28.10.2016.

Antitumor metallocenes [Cp2M]2+ (with Cp = cyclopentadienyl and M = Ti, V, Mo) and their Cp-functionalized analogues were found to be highly effective against tumor cell lines, even those that are resistant against cisplatin [(NH3)2Pt]2+ [1, 2]. Although the accumulation of the transition metals in the nucleus [3] points towards DNA as a major target, the interaction of metallocenes with nucleic acids has not been elucidated yet. Mass spectrometry represents the ideal method for the fast and reliable investigation of the formed metallodrug-adducts and allows the selective study of the adduct of interest. The presented tandem mass spectrometric study compares the adduct formation and the subsequent dissociation pathways upon CID with the dinucleoside monophosphate d(TpA) and four transition metals.

Item Type:

Conference or Workshop Item (Poster)

Division/Institute:

08 Faculty of Science > Departement of Chemistry and Biochemistry

UniBE Contributor:

Eberle, Rahel Patricia and Schürch, Stefan

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry
500 Science

Language:

English

Submitter:

Stefan Schürch

Date Deposited:

24 Jan 2017 17:17

Last Modified:

24 Jan 2017 17:17

URI:

https://boris.unibe.ch/id/eprint/92498

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