White matter correlates of the disorganized speech dimension in schizophrenia

Viher, Petra; Stegmayer, Katharina; Giezendanner, Stéphanie; Federspiel, Andrea; Bohlhalter, Stephan; Wiest, Roland; Strik, Werner; Walther, Sebastian (2018). White matter correlates of the disorganized speech dimension in schizophrenia. European archives of psychiatry and clinical neuroscience, 268(1), pp. 99-104. Springer 10.1007/s00406-016-0753-y

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Disorganized speech is related to functional abnormalities in schizophrenia. To test the association between formal thought disorders (FTDs) and white matter microstructure, we applied a behavioral rating and diffusion tensor imaging in 61 patients with schizophrenia spectrum disorders. The Bern Psychopathology Scale was used to rate the dimension of language abnormalities ranging from negative FTDs, basically unaltered speech, to positive FTDs. Tract-based spatial statistics indicated increased fractional anisotropy in left hemispheric pathways of the language system in patients with negative FTDs. Thus, altered white matter properties in relevant fiber tracts may represent vulnerability to specific formal thought disorders.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

Graduate School:

Graduate School for Health Sciences (GHS)

UniBE Contributor:

Viher, Petra; Stegmayer, Katharina; Giezendanner, Stéphanie; Federspiel, Andrea; Bohlhalter, Stephan; Wiest, Roland; Strik, Werner and Walther, Sebastian

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0940-1334

Publisher:

Springer

Language:

English

Submitter:

Martin Zbinden

Date Deposited:

10 Jan 2017 11:34

Last Modified:

25 Apr 2018 12:25

Publisher DOI:

10.1007/s00406-016-0753-y

PubMed ID:

28032254

Uncontrolled Keywords:

Bern, Psychopathology, Scale, Diffusion tensor imaging, Formal thought disorders, Language system, Tract-based spatial statistics

BORIS DOI:

10.7892/boris.92534

URI:

https://boris.unibe.ch/id/eprint/92534

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