National Institutes of Health Hematopoietic Cell Transplantation Late Effects Initiative: The Cardiovascular Disease and Associated Risk Factors Working Group Report

Armenian, Saro H; Chemaitilly, Wassim; Chen, Marcus; Chow, Eric J; Duncan, Christine N; Jones, Lee W; Pulsipher, Michael A; Remaley, Alan T; Rovó, Alicia; Salooja, Nina; Battiwalla, Minoo (2017). National Institutes of Health Hematopoietic Cell Transplantation Late Effects Initiative: The Cardiovascular Disease and Associated Risk Factors Working Group Report. Biology of blood and marrow transplantation, 23(2), pp. 201-210. Elsevier 10.1016/j.bbmt.2016.08.019

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A number of studies have shown that autologous and allogeneic hematopoietic cell transplantation (HCT) contribute to an increased incidence of cardiovascular disease (CVD) and worsening of cardiovascular risk factors that could contribute to further CVD over time. These observations, combined with a notable increase in the number of survivors after HCT in recent years, highlight the need for studies aimed at modifying risk or preventing these outcomes by changing specific approaches and/or post-HCT interventions. To address these issues, the National Heart, Lung and Blood Institute and National Cancer Institute co-sponsored an international initiative on late effects after HCT. This report summarizes the major gaps in knowledge along with detailed recommendations regarding study priorities from the Cardiovascular Disease and Associated Risk Factors Committee, a multidisciplinary panel of international experts. The committee calls for specific studies aimed at understanding and preventing arterial disease and cardiac dysfunction (heart failure, valvular disease, and arrhythmias), as well as decreasing cardiovascular risk factors (hypertension, hyperglycemia, dyslipidemia, and sarcopenic obesity) after HCT.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Haematology and Central Haematological Laboratory

UniBE Contributor:

Rovó, Alicia

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1083-8791

Publisher:

Elsevier

Language:

English

Submitter:

Katrin Kölliker-Schütz

Date Deposited:

15 Mar 2017 11:44

Last Modified:

15 Mar 2017 11:44

Publisher DOI:

10.1016/j.bbmt.2016.08.019

PubMed ID:

27590105

Uncontrolled Keywords:

Cardiovascular disease; Cardiovascular risk factors; Chronic disease; Hematopoietic cell transplantation; Late effects; National Institutes of Health consensus; Survivorship

BORIS DOI:

10.7892/boris.92538

URI:

https://boris.unibe.ch/id/eprint/92538

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