Percutaneous closure of patent foramen ovale: an underutilized prevention?

Nietlispach, Fabian; Meier, Bernhard (2016). Percutaneous closure of patent foramen ovale: an underutilized prevention? European Heart Journal, 37(26), pp. 2023-2028. Oxford University Press 10.1093/eurheartj/ehv376

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Stroke is a devastating event for patients and their families. Paradoxical embolism through a patent foramen ovale (PFO) is a recognized cause of stroke. Percutaneous PFO closure is a simple and safe procedure. The debate on PFO closure is far from settled. This is, in part, due to the fact that the three published randomized controlled trials (RCTs) on PFO closure vs. medical therapy were negative regarding their primary endpoint; however, as-treated and per-protocol analyses as well as several meta-analyses report a benefit of PFO closure. In our opinion, PFO closure is underutilized and the results of the three RCTs are not adequately reflected in the current guidelines.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Meier, Bernhard

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0195-668X

Publisher:

Oxford University Press

Language:

English

Submitter:

Daria Vogelsang

Date Deposited:

09 Mar 2017 09:46

Last Modified:

01 Aug 2019 02:30

Publisher DOI:

10.1093/eurheartj/ehv376

PubMed ID:

26248568

Uncontrolled Keywords:

PFO closure; Paradoxical embolism; Percutaneous; Prevention; Stroke

BORIS DOI:

10.7892/boris.92575

URI:

https://boris.unibe.ch/id/eprint/92575

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