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f
Q
EMC
EMC
1 0 0 1 -534.84497 -667.95197 cm
0.075 0.078 0.075 sc
BT
/T1_1 1 Tf
22.7999 0 0 24.0001 56.6929 651.28802 Tm
[ (Impact) -303 (of) ] TJ
/T1_2 1 Tf
22.7999 0 0 24.0001 154.89207 651.28802 Tm
[ (CYP19A1) ] TJ
/T1_1 1 Tf
22.7999 0 0 24.0001 243.67489 651.28802 Tm
[ (and) ] TJ
/T1_2 1 Tf
22.7999 0 0 24.0001 286.8807 651.28802 Tm
[ (ESR1) ] TJ
/T1_1 1 Tf
22.7999 0 0 24.0001 337.83847 651.28802 Tm
[ (variants) -304 (on) ] TJ
22.7999 0 0 24.0001 56.6929 625.27192 Tm
[ (early\055onset) -303 (side) -301 (effects) -305 (during) -300 (combined) ] TJ
1.082 TL
22.7999 0 0 24.0001 56.6929 599.30381 Tm
[ (endocrine) -303 (therapy) -303 (in) -298 (the) -302 (TEXT) -301 (trial) ] TJ
/T1_3 1 Tf
10.4499 0 0 11.0001 56.6929 575.26282 Tm
[ (Harriet) -303 (Johansson) ] TJ
7.8372 0 0 7.3327 131.13071 580.19513 Tm
[ (1\052) ] TJ
10.4499 0 0 11.0001 137.87711 575.26282 Tm
[ (\054) -301 (Kathryn) -303 (P\056) -305 (Gray) ] TJ
7.8372 0 0 7.3327 206.4189 580.19513 Tm
[ (2) ] TJ
10.4499 0 0 11.0001 210.1606 575.26282 Tm
[ (\054) -301 (Olivia) -306 (Pagani) ] TJ
7.8372 0 0 7.3327 269.00781 580.19513 Tm
[ (3\0544\0545) ] TJ
10.4499 0 0 11.0001 282.89761 575.26282 Tm
[ (\054) -301 (Meredith) -300 (M\056) -306 (Regan) ] TJ
7.8372 0 0 7.3327 367.5968 580.19513 Tm
[ (6) ] TJ
10.4499 0 0 11.0001 371.3952 575.26282 Tm
[ (\054) -301 (Giuseppe) -301 (Viale) ] TJ
7.8372 0 0 7.3327 437.83929 580.19513 Tm
[ (7) ] TJ
10.4499 0 0 11.0001 441.58099 575.26282 Tm
[ (\054) -301 (Valentina) -302 (Aristarco) ] TJ
7.8372 0 0 7.3327 523.95569 580.19513 Tm
[ (1) ] TJ
10.4499 0 0 11.0001 527.69751 575.26282 Tm
[ (\054) ] TJ
10.4499 0 0 11.0001 56.68916 561.25969 Tm
[ (Debora) -305 (Macis) ] TJ
7.8372 0 0 7.3327 113.8394 566.19202 Tm
[ (1) ] TJ
10.4499 0 0 11.0001 117.5811 561.2597 Tm
[ (\054) -301 (Antonella) -303 (Puccio) ] TJ
7.8372 0 0 7.3327 193.09599 566.19202 Tm
[ (1) ] TJ
10.4499 0 0 11.0001 196.8378 561.2597 Tm
[ (\054) -301 (Susanne) -305 (Roux) ] TJ
7.8372 0 0 7.3327 260.3338 566.19202 Tm
[ (8) ] TJ
10.4499 0 0 11.0001 264.1322 561.2597 Tm
[ (\054) -301 (Rudolf) -299 (Maibach) ] TJ
7.8372 0 0 7.3327 334.26141 566.19202 Tm
[ (8) ] TJ
10.4499 0 0 11.0001 338.00311 561.2597 Tm
[ (\054) -301 (Marco) -307 (Colleoni) ] TJ
7.8372 0 0 7.3327 406.03448 566.19202 Tm
[ (9) ] TJ
10.4499 0 0 11.0001 409.77631 561.2597 Tm
[ (\054) -301 (Manuela) -303 (Rabaglio) ] TJ
7.8372 0 0 7.3327 489.203 566.19202 Tm
[ (10) ] TJ
10.4499 0 0 11.0001 496.68649 561.2597 Tm
[ (\054) ] TJ
10.4499 0 0 11.0001 56.69347 547.25658 Tm
[ (Karen) -302 (N\056) -300 (Price) ] TJ
7.8372 0 0 7.3327 114.8031 552.18878 Tm
[ (11\05418) ] TJ
10.4499 0 0 11.0001 131.13071 547.25659 Tm
[ (\054) -301 (Alan) -298 (S\056) -304 (Coates) ] TJ
7.8372 0 0 7.3327 195.36369 552.18878 Tm
[ (12) ] TJ
10.4499 0 0 11.0001 202.9039 547.25659 Tm
[ (\054) -301 (Richard) -300 (D\056) -301 (Gelber) ] TJ
7.8372 0 0 7.3327 280.74329 552.18878 Tm
[ (13) ] TJ
10.4499 0 0 11.0001 288.28339 547.25659 Tm
[ (\054) -301 (Aron) -299 (Goldhirsch) ] TJ
7.8372 0 0 7.3327 361.02039 552.18878 Tm
[ (14) ] TJ
10.4499 0 0 11.0001 368.56049 547.25659 Tm
[ (\054) -301 (Roswitha) -300 (Kammler) ] TJ
7.8372 0 0 7.3327 451.21881 552.18878 Tm
[ (15) ] TJ
10.4499 0 0 11.0001 458.75891 547.25659 Tm
[ (\054) ] TJ
10.4499 0 0 11.0001 56.69904 533.30846 Tm
[ (Bernardo) -306 (Bonanni) ] TJ
7.8372 0 0 7.3327 131.86771 538.18573 Tm
[ (1) ] TJ
/T1_4 1 Tf
7.8372 0 0 7.3327 135.66875 538.18573 Tm
[ (\206) ] TJ
/T1_3 1 Tf
10.4499 0 0 11.0001 139.4079 533.31012 Tm
[ (\054) -301 (Barbara) -302 (A\056) -303 (Walley) ] TJ
7.8372 0 0 7.3327 216.51019 538.18573 Tm
[ (16\05417) ] TJ
/T1_4 1 Tf
7.8372 0 0 7.3327 232.83508 538.18573 Tm
[ (\206) ] TJ
/T1_3 1 Tf
10.4499 0 0 11.0001 239.6976 533.31012 Tm
[ (and) -602 (the) -305 (TEXT) -298 (principal) -304 (investigators) ] TJ
/T1_0 1 Tf
10.3 0 0 10.3 63.2126 494.75891 Tm
[ (Abstract) ] TJ
/T1_5 1 Tf
10.0001 0 0 10.0001 63.2126 476.78729 Tm
[ (Background\072) ] TJ
/T1_3 1 Tf
10.0001 0 0 10.0001 120.64318 476.78729 Tm
[ (Si) 20 (ng) 18 (le) -254 (nu) 14 (c) 12 (le) 12 (ot) 17 (id) 18 (e) -258 (po) 12 (ly) 16 (m) 13 (or) 17 (ph) 12 (is) 16 (ms) -253 (\050S) 15 (N) 11 (Ps) 14 (\051) -262 (in) -253 (th) 17 (e) -258 (es) 15 (tr) 15 (og) 18 (en) -254 (re) 16 (c) 12 (ep) 11 (t) 13 (or) -255 (1) -264 (\050) ] TJ
/T1_6 1 Tf
10.0001 0 0 10.0001 389.82586 476.78729 Tm
[ (ES) 18 (R1) ] TJ
/T1_3 1 Tf
10.0001 0 0 10.0001 407.62604 476.78729 Tm
[ (\051) -262 (a) 11 (nd) -255 (cy) 18 (to) 17 (ch) 16 (ro) 17 (me) -257 (P) 12 (45) 11 (0) -258 (19) 17 (A1) ] TJ
10.0001 0 0 10.0001 63.21257 464.76717 Tm
[ (\050) ] TJ
/T1_6 1 Tf
10.0001 0 0 10.0001 65.7026 464.76717 Tm
[ (CY) 18 (P1) 13 (9A) 20 (1) ] TJ
/T1_3 1 Tf
10.0001 0 0 10.0001 98.98293 464.76717 Tm
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1.202 TL
/T1_6 1 Tf
10.0001 0 0 10.0001 63.21258 440.78693 Tm
[ (CY) 18 (P1) 19 (9A) 14 (1) ] TJ
-0.0105 Tc
/T1_3 1 Tf
10.0001 0 0 10.0001 99.15294 440.78693 Tm
[ (an) -10 (d) ] TJ
0 Tc
/T1_6 1 Tf
10.0001 0 0 10.0001 116.78311 440.78693 Tm
[ (ES) 12 (R1) ] TJ
/T1_3 1 Tf
10.0001 0 0 10.0001 137.30332 440.78693 Tm
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10.0001 0 0 10.0001 63.20258 428.76681 Tm
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-0.0127 Tc
1.497 TL
/T1_5 1 Tf
10.0001 0 0 10.0001 63.20258 413.79666 Tm
[ (Me) -13 (th) -13 (o) 6 (d) -13 (s\072) ] TJ
-0.0144 Tc
/T1_3 1 Tf
10.0001 0 0 10.0001 105.383 413.79666 Tm
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-0.0141 Tc
10.0001 0 0 10.0001 322.43517 413.79666 Tm
[ (omen) -271 (with) -265 (h) -14 (o) 10 (rmo) -14 (n) 10 (e\055responsive) -266 (earl) -14 (y) -259 (breast) -268 (cancer\054) ] TJ
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10.0001 0 0 10.0001 63.20258 401.77654 Tm
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0 Tc
10.0001 0 0 10.0001 294.1649 401.77654 Tm
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10.0001 0 0 10.0001 63.20258 389.75642 Tm
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/T1_6 1 Tf
10.0001 0 0 10.0001 225.9642 389.75642 Tm
[ (C) 15 (Y) 14 (P) 15 (1) 16 (9A) 25 (1) ] TJ
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/T1_3 1 Tf
10.0001 0 0 10.0001 261.51456 389.75642 Tm
[ (\050rs4646) -266 (and) -267 (r) -1 (s10046\051) -270 (and) -272 (t) -1 (hree) ] TJ
-0.013 Tc
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[ (ES) 5 (R1) ] TJ
-0.0142 Tc
/T1_3 1 Tf
10.0001 0 0 10.0001 404.15598 389.75642 Tm
[ (\050rs2077647\054) -268 (rs22346) 6 (93) -272 (an) -14 (d) ] TJ
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[ (rs9340799\051) -270 (SNPs) -274 (by) -269 (a) -270 (r) -1 (eal\055time) -267 (pyrosequencing) -273 (techniqu) -14 (e) 15 (\056) -273 (Adverse) -272 (events) -268 (\050) -14 (A) 12 (E) 2 (s\051) -270 (were) -272 (recorded) -273 (at) -268 (basel) -14 (i) 11 (ne) -267 (and) -273 (3\055) ] TJ
0 Tc
1.202 TL
10.0001 0 0 10.0001 63.20255 365.77618 Tm
[ (m) 18 (on) 25 (t) 19 (hl) 25 (y) -255 (d) 14 (u) 15 (r) 13 (i) 15 (n) 15 (g) -258 (t) 13 (h) 15 (e) -252 (fi) 26 (r) 13 (s) 18 (t) -259 (y) 18 (e) 14 (a) 11 (r) 13 (\056) -253 (A) 16 (s) 13 (s) 13 (o) 15 (c) 12 (i) 15 (a) 16 (t) ] TJ
-0.0148 Tc
10.0001 0 0 10.0001 209.64402 365.77618 Tm
[ (ions) -274 (of) -271 (th) -15 (e) -258 (g) -1 (enotype) -267 (v) -4 (ariants) -274 (with) -272 (g) -1 (rade) ] TJ
0 Tc
/T1_7 1 Tf
10.0001 0 0 10.0001 370.42562 365.77618 Tm
[ <01> ] TJ
-0.0144 Tc
/T1_3 1 Tf
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[ (2) -267 (earl) -14 (y) 13 (\055onset) -268 (targeted) -273 (AEs) -274 (o) 1 (f) -270 (hot) ] TJ
-0.0138 Tc
10.0001 0 0 10.0001 63.20255 353.75606 Tm
[ (flas) 4 (hes\057sweat) 5 (i) 1 (n) -14 (g) -257 (or) -273 (muscul) -14 (o) 11 (s) -1 (k) 5 (el) -14 (e) 16 (tal) -265 (events) -268 (w) 1 (ere) -272 (a) 2 (ss) 4 (essed) -266 (u) -14 (s) 14 (i) -14 (n) 11 (g) -266 (lo) -14 (g) 9 (i) 1 (s) 4 (t) -1 (ic) -274 (r) 5 (egression) -271 (m) 5 (o) -14 (d) 9 (els) 4 (\056) ] TJ
-0.0142 Tc
1.497 TL
/T1_5 1 Tf
10.0001 0 0 10.0001 63.20255 338.78591 Tm
[ (Results\072) ] TJ
/T1_3 1 Tf
10.0001 0 0 10.0001 97.61289 338.78591 Tm
[ (T) -14 (h) 11 (ere) -267 (w) 1 (ere) -272 (2660) -267 (premenopau) -14 (s) 14 (a) -4 (l) -271 (patients) -268 (w) 1 (ith) -271 (breast) -268 (c) -2 (an) ] TJ
-0.015 Tc
10.0001 0 0 10.0001 320.69513 338.78591 Tm
[ (cer) -268 (i) -15 (n) -257 (t) -2 (he) -273 (intention\055to) -15 (\055) 13 (t) -2 (reat) -274 (populati) -15 (o) 10 (n) -266 (o) -15 (f) -261 (TEXT\054) -274 (and) ] TJ
-0.0145 Tc
10.0001 0 0 10.0001 63.19255 326.76579 Tm
[ (1967) -267 (\05074) -272 (\045\051) -270 (a) 2 (re) -272 (included) -273 (in) -271 (th) -14 (i) 10 (s) -268 (translation) -14 (a) 11 (l) -271 (s) 4 (tudy\056) -268 (T) -14 (h) 11 (e) ] TJ
-0.0153 Tc
/T1_6 1 Tf
10.0001 0 0 10.0001 278.96471 326.76579 Tm
[ (C) -15 (Y) 8 (P19A1) ] TJ
-0.0142 Tc
/T1_3 1 Tf
10.0001 0 0 10.0001 314.51507 326.76579 Tm
[ (rs10046) -266 (variant) -268 (T) 2 (\057T) -14 (\054) -258 (r) -1 (epresented) -273 (in) -271 (23) -266 (\045) -272 (o) 1 (f) -270 (w) 1 (omen\054) -273 (w) 1 (as) ] TJ
10.0001 0 0 10.0001 63.19255 314.74567 Tm
[ (associated) -267 (wi) -14 (t) 14 (h) -271 (a) -270 (r) -1 (educed) -267 (in) -14 (c) 13 (i) 1 (dence) -272 (o) 1 (f) -270 (grade) ] TJ
0 Tc
/T1_7 1 Tf
10.0001 0 0 10.0001 242.28435 314.74567 Tm
[ <01> ] TJ
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