Patients with an Orthotopic Low Pressure Bladder Substitute Enjoy Long-Term Good Function

Furrer, Marc; Roth, Beat; Kiss, Bernhard; Nguyen, Daniel Truong Phat; Boxler, Silvan; Burkhard, Fiona C.; Thalmann, George; Studer, Urs (2016). Patients with an Orthotopic Low Pressure Bladder Substitute Enjoy Long-Term Good Function. Journal of urology, 196(4), pp. 1172-1180. Elsevier 10.1016/j.juro.2016.04.072

Text 1-s2.0-S0022534716303202-main.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (623kB) | Request a copy

PURPOSE

Orthotopic bladder substitution has been performed on a regular basis for more than 30 years and yet data on long-term functional outcomes are still lacking.

MATERIALS AND METHODS

We evaluated 181 men and 19 women who underwent radical cystectomy and urinary diversion with ileal orthotopic bladder substitution from 1985 to 2004 and who had 10 years or more of followup.

RESULTS

Median age at radical cystectomy was 63 years (IQR 57-69). Median followup was 167 months (IQR 137-206). Daytime and nighttime continence rates peaked 24 months postoperatively and decreased slightly thereafter during almost 2 decades. At 10, 15 and 20 years daytime continence rates were 92%, 90% and 79%, and nighttime continence rates were 70%, 65% and 55%, respectively. During the day and at night fewer than 3% and 10% of patients, respectively, had urine loss 100 ml or greater at any time 10 years or longer after surgery. At 10 and 20 years 11 of 200 patients (6%) and 1 of 29 (3%), respectively, had to perform clean intermittent self-catheterization. After an initial postoperative decrease in the estimated glomerular filtration rate the subsequent decrease was less than 1 ml/minute/1.73 m(2) per year. A total of 81 complications were observed in 42 of the 200 patients (21%) 10 years or longer after radical cystectomy with pyelonephritis as the most frequent cause.

CONCLUSIONS

Patients who survive up to 20 years after radical cystectomy and diversion with an ileal orthotopic bladder substitution may enjoy satisfactory urinary continence and retain the ability to void spontaneously while experiencing no more than a physiological decrease in renal function.

Interest & Impact

Downloads

1 since deposited on 14 Mar 2017
0 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item