Oncological Outcomes of Patients with Concomitant Bladder and Urethral Carcinoma

Gakis, Georgios; Efstathiou, Jason A; Daneshmand, Siamak; Keegan, Kirk A; Clayman, Rebecca H; Hrbacek, Jan; Ali-El-Dein, Bedeir; Zaid, Harras B; Schubert, Tina; Mischinger, Johannes; Todenhöfer, Tilman; Galland, Sigolene; Olugbade, Kola; Rink, Michael; Fritsche, Hans-Martin; Burger, Maximilian; Chang, Sam S; Babjuk, Marko; Thalmann, George; Stenzl, Arnulf; ... (2016). Oncological Outcomes of Patients with Concomitant Bladder and Urethral Carcinoma. Urologia internationalis, 97(2), pp. 134-141. Karger 10.1159/000448335

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INTRODUCTION

The study aimed to investigate oncological outcomes of patients with concomitant bladder cancer (BC) and urethral carcinoma.

METHODS

This is a multicenter series of 110 patients (74 men, 36 women) diagnosed with urethral carcinoma at 10 referral centers between 1993 and 2012. Kaplan-Meier analysis was used to investigate the impact of BC on survival, and Cox regression multivariable analysis was performed to identify predictors of recurrence.

RESULTS

Synchronous BC was diagnosed in 13 (12%) patients, and the median follow-up was 21 months (interquartile range 4-48). Urethral cancers were of higher grade in patients with synchronous BC compared to patients with non-synchronous BC (p = 0.020). Patients with synchronous BC exhibited significantly inferior 3-year recurrence-free survival (RFS) compared to patients with non-synchronous BC (63.2 vs. 34.4%; p = 0.026). In multivariable analysis, inferior RFS was associated with clinically advanced nodal stage (p < 0.001), proximal tumor location (p < 0.001) and synchronous BC (p = 0.020).

CONCLUSION

The synchronous presence of BC in patients diagnosed with urethral carcinoma has a significant adverse impact on RFS and should be an impetus for a multimodal approach.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Urology

UniBE Contributor:

Thalmann, George

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0042-1138

Publisher:

Karger

Language:

English

Submitter:

Katharina Morgenegg

Date Deposited:

14 Mar 2017 16:33

Last Modified:

29 Jul 2017 02:30

Publisher DOI:

10.1159/000448335

PubMed ID:

27462702

BORIS DOI:

10.7892/boris.92730

URI:

https://boris.unibe.ch/id/eprint/92730

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