Prostate cancer radiation therapy: A physician's perspective.

Dal Pra, Alan; Souhami, Luis (2016). Prostate cancer radiation therapy: A physician's perspective. Physica medica, 32(3), pp. 438-445. Elsevier 10.1016/j.ejmp.2016.02.012

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Prostate cancer is the second most common cancer in men and a major cause of cancer deaths worldwide. Ionizing radiation has played a substantial role in the curative treatment of this disease. The historical evolution of radiotherapy techniques through 3D-conformal radiotherapy (3D-CRT), intensity-modulated radiotherapy (IMRT), and image-guided radiotherapy (IGRT) has allowed more accurate and precise treatments toward significant improvements in the therapeutic ratio. The addition of androgen deprivation therapy has significantly improved overall survival becoming the standard therapy for intermediate- and high-risk disease. Many randomized controlled trials have shown improved local control with dose escalation, and hypofractionated RT has been consolidated with proven efficacy and safe clinical results. However, several questions remain open in the radiotherapeutic management of prostate cancer patients and hopefully ongoing studies will shed light on these uncertainties. More individualized approaches are essential through better prognostic and novel predictive biomarkers of prostate radiotherapy response. Clinicians should critically interpret the evolving technologies in prostate cancer radiotherapy with important optimism but balancing the costs and the actual magnitude of clinical benefit. This article provides an overview of the basic aspects of radiotherapy treatment in localized prostate cancer from a physician's perspective.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology

UniBE Contributor:

Dal Pra, Alan

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1724-191X

Publisher:

Elsevier

Language:

English

Submitter:

Beatrice Scheidegger

Date Deposited:

11 Apr 2017 08:04

Last Modified:

11 Apr 2017 08:04

Publisher DOI:

10.1016/j.ejmp.2016.02.012

PubMed ID:

27056435

Uncontrolled Keywords:

3-D radiotherapy; IMRT; Image-guided radiotherapy; Prostate cancer; Radiotherapy

BORIS DOI:

10.7892/boris.92813

URI:

https://boris.unibe.ch/id/eprint/92813

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