Molinuevo, José L; Rabin, Laura A; Amariglio, Rebecca; Buckley, Rachel; Dubois, Bruno; Ellis, Kathryn A; Ewers, Michael; Hampel, Harald; Klöppel, Stefan; Rami, Lorena; Reisberg, Barry; Saykin, Andrew J; Sikkes, Sietske; Smart, Colette M; Snitz, Beth E; Sperling, Reisa; van der Flier, Wiesje M; Wagner, Michael; Jessen, Frank (2017). Implementation of subjective cognitive decline criteria in research studies. Alzheimer's & dementia, 13(3), pp. 296-311. Elsevier 10.1016/j.jalz.2016.09.012
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INTRODUCTION
Subjective cognitive decline (SCD) manifesting before clinical impairment could serve as a target population for early intervention trials in Alzheimer's disease (AD). A working group, the Subjective Cognitive Decline Initiative (SCD-I), published SCD research criteria in the context of preclinical AD. To successfully apply them, a number of issues regarding assessment and implementation of SCD needed to be addressed.
METHODS
Members of the SCD-I met to identify and agree on topics relevant to SCD criteria operationalization in research settings. Initial ideas and recommendations were discussed with other SCD-I working group members and modified accordingly.
RESULTS
Topics included SCD inclusion and exclusion criteria, together with the informant's role in defining SCD presence and the impact of demographic factors.
DISCUSSION
Recommendations for the operationalization of SCD in differing research settings, with the aim of harmonization of SCD measurement across studies are proposed, to enhance comparability and generalizability across studies.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Geriatric Psychiatry and Psychotherapy |
UniBE Contributor: |
Klöppel, Stefan |
Subjects: |
100 Philosophy > 150 Psychology 600 Technology > 610 Medicine & health |
ISSN: |
1552-5279 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Pascal Wurtz |
Date Deposited: |
28 Feb 2017 10:54 |
Last Modified: |
05 Dec 2022 15:01 |
Publisher DOI: |
10.1016/j.jalz.2016.09.012 |
PubMed ID: |
27825022 |
Uncontrolled Keywords: |
Alzheimer's disease, Harmonization, Operationalization, Preclinical SCD-I, Subjective cognitive decline (SDC) |
BORIS DOI: |
10.7892/boris.92818 |
URI: |
https://boris.unibe.ch/id/eprint/92818 |
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