Implementation of subjective cognitive decline criteria in research studies

Molinuevo, José L; Rabin, Laura A; Amariglio, Rebecca; Buckley, Rachel; Dubois, Bruno; Ellis, Kathryn A; Ewers, Michael; Hampel, Harald; Klöppel, Stefan; Rami, Lorena; Reisberg, Barry; Saykin, Andrew J; Sikkes, Sietske; Smart, Colette M; Snitz, Beth E; Sperling, Reisa; van der Flier, Wiesje M; Wagner, Michael; Jessen, Frank (2017). Implementation of subjective cognitive decline criteria in research studies. Alzheimer's & dementia, 13(3), pp. 296-311. Elsevier 10.1016/j.jalz.2016.09.012

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INTRODUCTION Subjective cognitive decline (SCD) manifesting before clinical impairment could serve as a target population for early intervention trials in Alzheimer's disease (AD). A working group, the Subjective Cognitive Decline Initiative (SCD-I), published SCD research criteria in the context of preclinical AD. To successfully apply them, a number of issues regarding assessment and implementation of SCD needed to be addressed. METHODS Members of the SCD-I met to identify and agree on topics relevant to SCD criteria operationalization in research settings. Initial ideas and recommendations were discussed with other SCD-I working group members and modified accordingly. RESULTS Topics included SCD inclusion and exclusion criteria, together with the informant's role in defining SCD presence and the impact of demographic factors. DISCUSSION Recommendations for the operationalization of SCD in differing research settings, with the aim of harmonization of SCD measurement across studies are proposed, to enhance comparability and generalizability across studies.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Geriatric Psychiatry and Psychotherapy

UniBE Contributor:

Klöppel, Stefan

Subjects:

100 Philosophy > 150 Psychology
600 Technology > 610 Medicine & health

ISSN:

1552-5279

Publisher:

Elsevier

Language:

English

Submitter:

Pascal Wurtz

Date Deposited:

28 Feb 2017 10:54

Last Modified:

31 Jan 2019 11:04

Publisher DOI:

10.1016/j.jalz.2016.09.012

PubMed ID:

27825022

Uncontrolled Keywords:

Alzheimer's disease, Harmonization, Operationalization, Preclinical SCD-I, Subjective cognitive decline (SDC)

BORIS DOI:

10.7892/boris.92818

URI:

https://boris.unibe.ch/id/eprint/92818

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