Role of Dose Intensification for Salvage Radiation Therapy after Radical Prostatectomy.

Beck, Marcus; Barelkowski, Tomasz; Kaul, David; Wecker, Sascha; Thieme, Alexander H; Zwahlen, Daniel R; Wust, Peter; Aebersold, Daniel; Budach, Volker; Ghadjar, Pirus (2016). Role of Dose Intensification for Salvage Radiation Therapy after Radical Prostatectomy. Frontiers in oncology, 6(48), p. 48. Frontiers Research Foundation 10.3389/fonc.2016.00048

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For primary radiation therapy (RT) of prostate cancer, dose intensification is established as standard of care. Less is known on the role of dose intensification in the postprostatectomy setting for salvage RT. Thus, we aimed to identify and summarize the existing literature. In retrospective analyses, dose-intensified salvage RT showed a superior biochemical control compared to standard dose salvage radiation with favorable acute and late gastrointestinal and genitourinary toxicity rates, especially when modern radiation techniques such as intensity modulated RT were applied. We identified one randomized phase III trial addressing the potential benefits of dose-intensified salvage RT (SAKK 09/10). Recently, acute gastrointestinal and genitourinary toxicities and early quality of life data of this trial were reported, and no significant difference in acute toxicities between both treatment arms were found; however, a significant worsening of genitourinary quality of life was noted in the dose-intensified treatment arm. Whereas dose-intensified salvage RT appears to be feasible and well tolerated, the improved biochemical control rates using dose intensified RT as suggested by retrospective analyses have yet to be validated by prospective trials.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology

UniBE Contributor:

Aebersold, Daniel and Ghadjar, Pirus

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2234-943X

Publisher:

Frontiers Research Foundation

Language:

English

Submitter:

Beatrice Scheidegger

Date Deposited:

11 Apr 2017 09:32

Last Modified:

16 Apr 2017 02:22

Publisher DOI:

10.3389/fonc.2016.00048

PubMed ID:

26973815

Uncontrolled Keywords:

dose; prostate cancer; prostatectomy; radiation therapy; salvage

BORIS DOI:

10.7892/boris.92820

URI:

https://boris.unibe.ch/id/eprint/92820

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