[Antithrombotic therapy in patients undergoing transcatheter aortic valve implantation].

Gargiulo, Giuseppe; Valgimigli, Marco (2016). [Antithrombotic therapy in patients undergoing transcatheter aortic valve implantation]. Giornale italiano di cardiologia, 17(6), 4S-10S. Il Pensiero Scientifico Ed. 10.1714/2292.24636

[img] Text
http___www.giornaledicardiologia.it_r.php_v=2292&a=24636&l=326782&f=allegati_02292_2016_06_fulltext_02 Gargiulo (4-10).pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (220kB) | Request a copy

Transcatheter aortic valve implantation (TAVI) has emerged as a valid alternative to surgical replacement in patients with severe aortic stenosis. Bleeding and cerebral ischemic events remain frequent complications of this procedure during the periprocedural period and at follow-up with a severe impact on survival. Therefore, there is growing interest towards the optimal antithrombotic therapy to manage patients undergoing TAVI. International guidelines support the adoption of a dual antiplatelet therapy after TAVI, although there is heterogeneity in the suggested duration and the concomitant association with an oral anticoagulant in patients with specific indications, mainly those with atrial fibrillation. Recent data have questioned the benefits of adding clopidogrel to aspirin, showing a slight increase in bleeding compared with aspirin therapy alone. Importantly, recent studies have also underlined the risks of valve thrombosis and the potential benefits of oral anticoagulant therapy in patients undergoing TAVI. Currently, large randomized trials are ongoing and are expected to provide relevant information to guide recommendations on the most appropriate antithrombotic therapy in these patients. Tailored therapy based on the patient's risk profile remains relevant in daily clinical practice.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Gargiulo, Giuseppe and Valgimigli, Marco

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1827-6806

Publisher:

Il Pensiero Scientifico Ed.

Language:

Italiano

Submitter:

Daria Vogelsang

Date Deposited:

11 Apr 2017 15:35

Last Modified:

11 Oct 2017 08:59

Publisher DOI:

10.1714/2292.24636

PubMed ID:

27384599

BORIS DOI:

10.7892/boris.92855

URI:

https://boris.unibe.ch/id/eprint/92855

Actions (login required)

Edit item Edit item
Provide Feedback