Mitochondrial translation in trypanosomatids: a novel target for chemotherapy?

Niemann, Moritz; Schneider, André; Cristodero, Marina (2011). Mitochondrial translation in trypanosomatids: a novel target for chemotherapy? Trends in parasitology, 27(10), pp. 429-433. Oxford: Elsevier Current Trends 10.1016/j.pt.2011.03.011

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Trypanosomatids cause widespread disease in humans and animals. Treatment of many of these diseases is hampered by the lack of efficient and safe drugs. New strategies for drug development are therefore urgently needed. It has long been known that the single mitochondrion of trypanosomatids exhibits many unique features. Recently, the mitochondrial translation machinery of trypanosomatids has been the focus of several studies, which revealed interesting variations to the mammalian system. It is the aim of this article to review these unique features and to discuss them in the larger biological context. It is our opinion that some of these features represent promising novel targets for chemotherapeutic intervention that should be studied in more detail.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Departement of Chemistry and Biochemistry

UniBE Contributor:

Schneider, André

ISSN:

1471-4922

Publisher:

Elsevier Current Trends

Language:

English

Submitter:

Christina Schüpbach

Date Deposited:

04 Oct 2013 14:26

Last Modified:

11 Nov 2016 16:11

Publisher DOI:

10.1016/j.pt.2011.03.011

Web of Science ID:

000295748900003

BORIS DOI:

10.7892/boris.9286

URI:

https://boris.unibe.ch/id/eprint/9286 (FactScience: 214983)

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