Reducing Microvascular Dysfunction in Revascularized Patients with ST-Elevation Myocardial Infarction by Off-Target Properties of Ticagrelor versus Prasugrel. Rationale and Design of the REDUCE-MVI Study.

Janssens, Gladys N; van Leeuwen, Maarten A H; van der Hoeven, Nina W; de Waard, Guus A; Nijveldt, Robin; Diletti, Roberto; Zijlstra, Felix; von Birgelen, Clemens; Escaned, Javier; Valgimigli, Marco; van Royen, Niels (2016). Reducing Microvascular Dysfunction in Revascularized Patients with ST-Elevation Myocardial Infarction by Off-Target Properties of Ticagrelor versus Prasugrel. Rationale and Design of the REDUCE-MVI Study. Journal of cardiovascular translational research JCTR, 9(3), pp. 249-256. Springer 10.1007/s12265-016-9691-3

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Microvascular injury is present in a large proportion of patients with ST-elevation myocardial infarction (STEMI) despite successful revascularization. Ticagrelor potentially mitigates this process by exerting additional adenosine-mediated effects. This study aims to determine whether ticagrelor is associated with a better microvascular function compared to prasugrel as maintenance therapy after STEMI. A total of 110 patients presenting with STEMI and additional intermediate stenosis in another coronary artery will be studied after successful percutaneous coronary intervention (PCI) of the infarct-related artery. Patients will be randomized to treatment with ticagrelor or prasugrel for 1 year. FFR-guided PCI of the non-infarct-related artery will be performed at 1 month. Microvascular function will be assessed by measurement of the index of microcirculatory resistance (IMR) in the infarct-related artery and non-infarct-related artery, immediately after primary PCI and after 1 month. The REDUCE-MVI study will establish whether ticagrelor as a maintenance therapy may improve microvascular function in patients after revascularized STEMI.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Valgimigli, Marco

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1937-5387

Publisher:

Springer

Language:

English

Submitter:

Daria Vogelsang

Date Deposited:

12 Apr 2017 11:08

Last Modified:

12 Apr 2017 11:08

Publisher DOI:

10.1007/s12265-016-9691-3

PubMed ID:

27102290

Uncontrolled Keywords:

Adenosine; Microvascular injury; Prasugrel; ST-elevation myocardial infarction; Ticagrelor

BORIS DOI:

10.7892/boris.92869

URI:

https://boris.unibe.ch/id/eprint/92869

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