Janssens, Gladys N; van Leeuwen, Maarten A H; van der Hoeven, Nina W; de Waard, Guus A; Nijveldt, Robin; Diletti, Roberto; Zijlstra, Felix; von Birgelen, Clemens; Escaned, Javier; Valgimigli, Marco; van Royen, Niels (2016). Reducing Microvascular Dysfunction in Revascularized Patients with ST-Elevation Myocardial Infarction by Off-Target Properties of Ticagrelor versus Prasugrel. Rationale and Design of the REDUCE-MVI Study. Journal of cardiovascular translational research JCTR, 9(3), pp. 249-256. Springer 10.1007/s12265-016-9691-3
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Microvascular injury is present in a large proportion of patients with ST-elevation myocardial infarction (STEMI) despite successful revascularization. Ticagrelor potentially mitigates this process by exerting additional adenosine-mediated effects. This study aims to determine whether ticagrelor is associated with a better microvascular function compared to prasugrel as maintenance therapy after STEMI. A total of 110 patients presenting with STEMI and additional intermediate stenosis in another coronary artery will be studied after successful percutaneous coronary intervention (PCI) of the infarct-related artery. Patients will be randomized to treatment with ticagrelor or prasugrel for 1 year. FFR-guided PCI of the non-infarct-related artery will be performed at 1 month. Microvascular function will be assessed by measurement of the index of microcirculatory resistance (IMR) in the infarct-related artery and non-infarct-related artery, immediately after primary PCI and after 1 month. The REDUCE-MVI study will establish whether ticagrelor as a maintenance therapy may improve microvascular function in patients after revascularized STEMI.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology |
UniBE Contributor: |
Valgimigli, Marco |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1937-5387 |
Publisher: |
Springer |
Language: |
English |
Submitter: |
Daria Vogelsang |
Date Deposited: |
12 Apr 2017 11:08 |
Last Modified: |
05 Dec 2022 15:01 |
Publisher DOI: |
10.1007/s12265-016-9691-3 |
PubMed ID: |
27102290 |
Uncontrolled Keywords: |
Adenosine; Microvascular injury; Prasugrel; ST-elevation myocardial infarction; Ticagrelor |
BORIS DOI: |
10.7892/boris.92869 |
URI: |
https://boris.unibe.ch/id/eprint/92869 |
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