Usemann, Jakob; Frey, Urs; Mack, Ines; Schmidt, Anne; Gorlanova, Olga; Röösli, Martin; Hartl, Dominik; Latzin, Philipp (2016). CHI3L1 polymorphisms, cord blood YKL-40 levels and later asthma development. BMC pulmonary medicine, 16(1), p. 81. BioMed Central 10.1186/s12890-016-0239-8
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BACKGROUND
Single nucleotide polymorphisms (SNPs) in chitinase 3-like 1 (CHI3L1), the gene encoding YKL-40, and increased serum YKL-40 levels are associated with severe forms of asthma. It has never been addressed whether SNPs in CHI3L1 and cord blood YKL-40 levels could already serve as potential biomarkers for milder forms of asthma. We assessed in an unselected population whether SNPs in CHI3L1 and cord blood YKL-40 levels at birth are associated with respiratory symptoms, lung function changes, asthma, and atopy.
METHODS
In a prospective birth cohort of healthy term-born neonates (n = 260), we studied CHI3L1 polymorphisms, and measured cord blood YKL-40 levels by ELISA in (n = 170) infants. Lung function was performed at 5 weeks and 6 years. Respiratory health during the first year of life was assessed weekly by telephone interviews. Diagnosis of asthma and allergic sensitisation was assessed at 6 years (n = 142).
RESULTS
The SNP rs10399805 was significantly associated with asthma at 6 years. The odds ratio for asthma was 4.5 (95 % CI 1.59-12.94) per T-allele. This finding was unchanged when adjusting for cord blood YKL-40 levels. There was no significant association for cord blood YKL-40 levels and asthma. SNPs in CHI3L1 and cord blood YKL-40 were not associated with lung function measurements at 5 weeks and 6 years, respiratory symptoms in the first year, and allergic sensitisation at 6 years.
CONCLUSION
Genetic variation in CHI3L1 might be related to the development of milder forms of asthma. Larger studies are warranted to establish the role of YKL-40 in that pathway.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine 04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM) |
UniBE Contributor: |
Mack, Ines, Röösli, Martin, Latzin, Philipp |
Subjects: |
600 Technology > 610 Medicine & health 300 Social sciences, sociology & anthropology > 360 Social problems & social services |
ISSN: |
1471-2466 |
Publisher: |
BioMed Central |
Language: |
English |
Submitter: |
Anette van Dorland |
Date Deposited: |
20 Feb 2017 10:33 |
Last Modified: |
05 Dec 2022 15:01 |
Publisher DOI: |
10.1186/s12890-016-0239-8 |
PubMed ID: |
27193312 |
Uncontrolled Keywords: |
Asthma; CHI3L1 protein; Children; Cohort study; Cord blood; Genetic association study; Genetic variation; Infants; YKL-40 protein |
BORIS DOI: |
10.7892/boris.92911 |
URI: |
https://boris.unibe.ch/id/eprint/92911 |
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