Function and Ventilation of Large and Small Airways in Children and Adolescents with Inflammatory Bowel Disease.

Yammine, Sophie; Nyilas, Sylvia Meryl; Casaulta Aebischer, Carmen; Schibli, Susanne; Latzin, Philipp; Sokollik, Christiane (2016). Function and Ventilation of Large and Small Airways in Children and Adolescents with Inflammatory Bowel Disease. Inflammatory bowel diseases, 22(8), pp. 1915-1922. Lippincott Williams & Wilkins 10.1097/MIB.0000000000000779

[img] Text
00054725-201608000-00014.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (275kB) | Request a copy

BACKGROUND Extraintestinal manifestations are common among patients with inflammatory bowel disease (IBD), whereas pulmonary involvement is considered rare. However, chronic lung diseases begin with subclinical changes of the small airways and often originate in childhood. Pulmonary involvement, particularly of the small airways, can be assessed using novel inert gas washout tests. METHODS In this prospective, single-center study, 30 children and adolescents (mean age, 14 years; SD, ±2.6; 13 boys) with IBD (mean disease duration, 3.2 years; SD, ±2.8), and 32 healthy age-matched controls, performed nitrogen multiple-breath washout, double-tracer gas single-breath washout, and diffusion capacity for carbon monoxide. Patients with IBD additionally performed spirometry, plethysmography, and measurement of exhaled nitric oxide. RESULTS Patients with IBD demonstrated no abnormalities in classical lung function tests. There was no difference between active disease and remission. The lung clearance index, a very sensitive indicator for small airway function, did not differ between patients with IBD and healthy controls (mean difference [95% confidence interval] -0.01 [-0.28 to 0.25]). Specific markers for peripheral lung ventilation (Sacin and Scond) were also within the normal range (0.002 [-0.003 to 0.008] and -0.002 [-0.020 to 0.015], respectively). No association was found between measures of lung function and IBD subtype, clinical disease activity scores, laboratory values, treatment modalities, or disease duration. CONCLUSIONS In our cohort of pediatric and adolescent patients with IBD without respiratory symptoms, there was no evidence of significant lung disease on extensive screening testing. General screening of asymptomatic patients therefore appears unnecessary and is not recommended in this population.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Pneumologie (Pädiatrie)

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Yammine, Sophie; Nyilas, Sylvia Meryl; Casaulta Aebischer, Carmen; Schibli, Susanne; Latzin, Philipp and Sokollik, Christiane

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1078-0998

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

André Schaller

Date Deposited:

17 Feb 2017 17:16

Last Modified:

17 Feb 2017 17:16

Publisher DOI:

10.1097/MIB.0000000000000779

PubMed ID:

27120569

BORIS DOI:

10.7892/boris.92912

URI:

https://boris.unibe.ch/id/eprint/92912

Actions (login required)

Edit item Edit item
Provide Feedback