Ros, Carlos; Belák, Sándor (2002). Characterization of the glycoprotein B gene from ruminant alphaherpesviruses. Virus genes, 24(2), pp. 99-105. Nijhoff 10.1023/A:1014504730475
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The complete open reading frame and promoter region of the glycoprotein B (gB) gene has been identified and sequenced from five poorly characterized alphaherpesviruses of ruminants, bovine herpesvirus 5 (BHV-5), buffalo herpesvirus 1 (BuHV-1), cervine herpesvirus 1 (CerHV-1), rangiferine herpesvirus 1 (RanHV-1), and caprine herpesvirus 1 (CapHV-1). One of the two regions identified with considerable sequence and length variation is also target of the immune system, as two B cell epitopes have been identified in this location. Features shared with bovine herpesvirus 1 (BHV-1) gB include two broad hydrophobic regions, six N-glycosylation sites and ten conserved cysteine residues in the gB extracellular domain. Phylogenetic analysis showed that the studied ruminant alphaherpesviruses form, together with BHV-1, a consistent group within the alpha2 subgroup of the herpesviruses. BHV-5 and BuHV-1 are most closely related to BHV-1, followed by CerHV-1, RanHV-1 and more distantly by CapHV-1. A remarkable high degree of sequence similarity was observed between BuHV-1 and the neuropathogenic BHV-5.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP) |
UniBE Contributor: |
Ros Bascunana, Carlos |
Subjects: |
500 Science > 570 Life sciences; biology 500 Science > 540 Chemistry |
ISSN: |
0920-8569 |
Publisher: |
Nijhoff |
Language: |
English |
Submitter: |
Carlos Ros Bascunana |
Date Deposited: |
03 Jun 2021 14:38 |
Last Modified: |
05 Dec 2022 15:01 |
Publisher DOI: |
10.1023/A:1014504730475 |
PubMed ID: |
12018712 |
BORIS DOI: |
10.48350/92954 |
URI: |
https://boris.unibe.ch/id/eprint/92954 |
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