Circulating chromogranin B levels in patients with acute respiratory failure: data from the FINNALI Study.

Myhre, Peder Langeland; Stridsberg, Mats; Linko, Rita; Okkonen, Marjatta; Nygård, Ståle; Christensen, Geir; Pettilä, Ville Yrjö Olavi; Omland, Torbjørn; Røsjø, Helge (2017). Circulating chromogranin B levels in patients with acute respiratory failure: data from the FINNALI Study. Biomarkers, 22(8), pp. 775-781. Taylor & Francis 10.1080/1354750X.2016.1269200

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PURPOSE Circulating chromogranin B (CgB) levels are increased in situations characterized by systemic and myocardial stress, but whether CgB provides prognostic information in patients with acute respiratory failure (ARF) is unknown. METHODS We included 584 patients with ARF, defined as ventilatory support >6 h, and with blood samples available on Intensive Care Unit (ICU) admission and day 3 (n = 479). CgB levels were measured by radioimmunoassay and follow-up was 90 days. RESULTS One-hundred-sixty-nine patients (29%) died during follow-up. Admission CgB levels separated non-survivors from survivors: median 1234 (Q1-3 989-1742) vs. 917 (753-1224) pmol/L, respectively, p < 0.001. CgB levels on ICU admission (logarithmically transformed) were associated with time to death after adjustment for established risk indices available on ICU admission, including N-terminal pro-B-type natriuretic levels: HR 2.62 (95%C.I. 1.82-3.77), p < 0.001. Admission CgB levels also improved prognostication on top of SOFA and SAPS II scores as assessed by Cox regression analyses and the category-free net reclassification index. The area under the curve (AUC) for admission CgB levels to separate survivors and non-survivors was 0.72 (95%CI 0.67-0.76), while the AUC on day 3 was 0.60 (0.54-0.66). CONCLUSIONS CgB levels measured on ICU admission provided additional prognostic information to established risk indices in ARF patients.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic of Intensive Care

UniBE Contributor:

Pettilä, Ville Yrjö Olavi

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1366-5804

Publisher:

Taylor & Francis

Language:

English

Submitter:

Mirella Aeberhard

Date Deposited:

11 Jul 2017 16:35

Last Modified:

10 Nov 2017 01:30

Publisher DOI:

10.1080/1354750X.2016.1269200

PubMed ID:

28049363

Uncontrolled Keywords:

Chromogranin B; acute respiratory failure; biomarker prognosis

URI:

https://boris.unibe.ch/id/eprint/92995

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