[Ocular Manifestations in Sarcoidosis].

Walscheid, K; Tappeiner, Christoph; Heiligenhaus, A (2016). [Ocular Manifestations in Sarcoidosis]. Klinische Monatsblätter für Augenheilkunde, 233(5), pp. 594-600. Thieme 10.1055/s-0042-104063

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Sarcoidosis is an inflammatory multi-organ disease of unknown pathogenesis, characterised by non-necrotising granulomata. Sarcoidosis predominantly manifests in the lung, but any other organ may be affected. Ocular involvement is present in about 25 to 50 % of patients. The most common ocular manifestation is uveitis, especially of the anterior eye segment. If ocular sarcoidosis is suspected, interdisciplinary assessment of the patient is mandatory, including laboratory tests, chest X-ray, assessment by a specialist in internal medicine and, ideally, histological evidence of granuloma formation in a tissue specimen. Other (infectious) causes of granulomatous inflammation need to be excluded, especially tuberculosis or syphilis. For the ophthalmological assessment, detection of granulomatous lesions is of particular importance, especially by visualising chorioretinal granuloma by fluorescein and indocyanin green angiography. Cystoid macular oedema and glaucoma are the most frequent complications limiting visual acuity. Corticosteroids, which can be administered either locally or systemically, are the mainstay of therapy. Depending on the clinical course and the development of ocular complications, systemic steroid-sparing immunosuppressive medication may be indicated.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology

UniBE Contributor:

Tappeiner, Christoph

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1439-3999

Publisher:

Thieme

Language:

German

Submitter:

Christoph Tappeiner

Date Deposited:

18 Apr 2019 14:12

Last Modified:

18 Apr 2019 14:12

Publisher DOI:

10.1055/s-0042-104063

PubMed ID:

27187879

URI:

https://boris.unibe.ch/id/eprint/93128

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