Thrombophilia testing: Update, guidelines in the greyzones

Angelillo-Scherrer, Anne; Nagler, Michael (2016). Thrombophilia testing: Update, guidelines in the greyzones. Therapeutische Umschau, 73(10), pp. 626-634. Huber 10.1024/0040-5930/a000843

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Thrombophilias are hereditary or acquired conditions predisposing patients to thromboembolism. Testing for thrombophilia is commonly performed in patients with venous thromboembolism (VTE) and their relatives. However, no consensus exists for such testing that also usually does not provide information that impacts management. We review thrombophilia testing in the following clinical situations: Provoked VTE, unprovoked (idiopathic) VTE, in relatives of patients with VTE, in female relatives of patients with VTE considering estrogen use, in female relatives of patients with VTE who are considering pregnancy. We also propose a list of thrombophilia parameters to test and the timing of thrombophilia testing. We suggest that thrombophilia testing not be performed in most situations. When performed, it should be used in a highly selective manner, and only in circumstances where the information obtained will impact a decision important to the patient, and outweigh the potential risks of testing. Testing could also be requested by the patient on a subjective basis. Therefore a pre-test counseling as well as a proper interpretation of laboratory tests are mandatory. Testing should not be performed during acute VTE nor during the initial 3-month period of anticoagulation.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Haematology and Central Haematological Laboratory
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Hämatologie (Erwachsene)

UniBE Contributor:

Angelillo, Anne and Nagler, Michael

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0040-5930

Publisher:

Huber

Language:

German

Submitter:

Katrin Kölliker-Schütz

Date Deposited:

22 Feb 2017 12:25

Last Modified:

30 Sep 2017 16:23

Publisher DOI:

10.1024/0040-5930/a000843

PubMed ID:

28045363

Uncontrolled Keywords:

Angelillo-Scherrer Anne, Nagler Michael

BORIS DOI:

10.7892/boris.93145

URI:

https://boris.unibe.ch/id/eprint/93145

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