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Rebecca A. M. Blom, Silvia T. Erni, Kristína Krempaská, Olivier Schaerer, R. Maarten van Dijk, Mario Amacker, Christian Moser, Sean R. R. Hall, Christophe von Garnier, Fabian Blank
A Triple Co-Culture Model of the Human Respiratory Tract to Study Immune-Modulatory Effects of Liposomes and Virosomes
www.plosone.org
www.plosone.org
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[(3)14(3)]TJ
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[()-19()]TJ
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[(3)9()-19( )]TJ
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[(&*)]TJ
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[(!")]TJ
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[(6)17()]TJ
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[()8()4()]TJ
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[()1(\n)-11(\n)8()-6()-6()]TJ
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[( )11(\n)]TJ
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[()1()2(\n)-17()12()2()1(/)]TJ
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[( )11()]TJ
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[()8()1()13()]TJ
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[()-3()12()-4()]TJ
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[()-13()14()7()20()]TJ
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[()1()11()12()-4()4()5()1()-2()-4()]TJ
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[()-1()5()-5()3()]TJ
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[(\()5(>8$)]TJ
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[()8()4()]TJ
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[($)22('3)]TJ
ET
Q
q
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BT
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[(A)]TJ
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Q
q
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BT
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[()6( )11()]TJ
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[()4( )11()4( )-6()-5()12()10()1()13()2()]TJ
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[()13()1()11()13()2()-7()1()19()-5()1()8()]TJ
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[()-1()5()-5()3()]TJ
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[( )11(\n)]TJ
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[()-4()4()]TJ
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[()-2()8()8()7()1()]TJ
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[()8()4()]TJ
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[()2()3()-4()-5()2()1()]TJ
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[()8()1()-29()1()18()1()]TJ
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[()13()2()5()-9()-6()-6()-5()7(\r)8()5()7()]TJ
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[()8()13()]TJ
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[()10()-9()]TJ
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[()6()-2()18()8()1()7()]TJ
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[()6( )]TJ
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Q
q
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BT
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ET
Q
q
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BT
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[(\n)-17()12()2( )11()13()6()2()13( )11()4()]TJ
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[(#)9(\()5(\()5($)]TJ
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[(#)3()2()-6( )15()-7(\))-5()-4()1()2()12()6( )15()-7()]TJ
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[()2()-6()7()8()-1()1()13( &)6()4( )1()5()6()4( )-9()1()-4()3()8()4( )6()-2()8()2()1()4()]TJ
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[(C)]TJ
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[()-6()7()8()-1( )6()]TJ
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Q
q
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BT
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ET
Q
q
1 j
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BT
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[()4( )1()5()6()4( )-9()6()4( )6()1()1()4(C)]TJ
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Q
q
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BT
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[(&)]TJ
ET
Q
q
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BT
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q
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BT
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BT
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[(6)17()23(\r)-3()12()-5()13( )1()7()1()]TJ
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[()-9()1()2()2()-5()-5()1()1(=)5()-5()13()1()11()6( )11()23()8()1()]TJ
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[(;;)]TJ
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[()-7(#)]TJ
ET
Q
q
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BT
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[(&)]TJ
ET
Q
q
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BT
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(\r)Tj
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[(&-)]TJ
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Q
q
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11.9999 0 0 11.9999 200.0125 288.6236 cm
BT
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q
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BT
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BT
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ET
Q
q
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BT
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ET
Q
q
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1 J
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BT
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11.9999 0 0 11.9999 200.0125 178.0157 cm
BT
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BT
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0.83 0.64 0.02 0 k
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q
1 j
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BT
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(Statistics)Tj
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q
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0.83 0.64 0.02 0 k
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[()-6()1()6()2( )11(&)]TJ
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0.83 0.64 0.02 0 k
[(\)\))]TJ
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ET
Q
q
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BT
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ET
Q
q
1 j
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BT
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3.1918 0 Td
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0 g
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[(8)25()8()4( )11()-5()8()-10()-5()2()6()2()]TJ
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ET
Q
q
0.45 0.36 0.35 0.01 k
1 j
1 J
0 w
199.9998 269.6689 m
575.9997 269.6689 l
575.9997 269.1689 l
199.9998 269.1689 l
f*
307.3589 269.1689 m
307.3589 243.1689 l
306.8589 243.669 l
306.8589 269.1689 l
f*
307.3589 243.1689 m
199.9998 243.1689 l
199.9998 243.669 l
306.8589 243.669 l
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[()-2()18()-6()]TJ
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[()4( )11()]TJ
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[()5()4( )15()-3(")]TJ
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[(6)17()]TJ
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[()2()-9( )1()5()1()13()]TJ
3.7927 0 Td
[()2()-9()1()-4()1()4()1()19()]TJ
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[()1()2(\n)-17()12()2()1(/)]TJ
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[(\r)-3()1()13( )1()-7( )11()4()2()]TJ
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[()8()1()13()]TJ
-34.7525 -1.2983 Td
[(\n)-7()1()-10()-4()4()1()]TJ
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[()1()19()6()2( )15()8()-6()]TJ
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[()]TJ
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[()-1( )11()4()-1()1()19()-5()18()-5()2( )11()]TJ
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[( )11(\n)]TJ
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[(-)]TJ
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[(B=)-5()]TJ
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[(>)38(')]TJ
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[()-7()4()1()13()-5()1()]TJ
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[()1()12()-9( )1()-7( )11()4()2()]TJ
4.2123 0 Td
[()8()4()]TJ
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[(\()5(0<)]TJ
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[()8()1()13()]TJ
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[()12()-5()-5()1(/)-2()-6()]TJ
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[()18()]TJ
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[()-4()4()]TJ
1.474 0 Td
[()-6()8()4()]TJ
2.2507 0 Td
[()1()-5()12()12()-5()2( )11()]TJ
3.3788 0 Td
[(\n)-1()2()-6()6( )11()64(")]TJ
2.7553 0 Td
[(5)-3( )11()12()-5()1()4()]TJ
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[()1()4()2( )11()6( )16()1()]TJ
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[()4()-5()1()5()1()13()1()4()1()19()]TJ
5.9981 0 Td
[( )11(\n)]TJ
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[(\r)-3()1()13( )1()-7( )11()4()2()]TJ
4.2689 0 Td
[()8()4()]TJ
1.7178 0 Td
[()1()12()-9( )1()-7( )11()4()2()]TJ
4.2179 0 Td
[()15()]TJ
-35.6822 -1.3039 Td
[(7)-9('7)]TJ
1.9729 0 Td
[()6()2()5()]TJ
1.6044 0 Td
[()-3()2()5()2()2()-6()]TJ
3.067 0 Td
[()-1( )11()8()2()3()5()6()1()19()]TJ
4.235 0 Td
[()13()2()5()-5()12()]TJ
2.8062 0 Td
[()-9()5()2( )15()]TJ
2.5625 0 Td
[()-4()4()]TJ
1.474 0 Td
[()-4()2()13()2()5()4( )6()2()]TJ
4.0025 0 Td
[( )11(\n)]TJ
1.0148 0 Td
[(;";)]TJ
1.8766 0 Td
[($H=)-5()]TJ
2.8969 0 Td
[()1()]TJ
1.0262 0 Td
[()-4()4()]TJ
1.4683 0 Td
[()-1( )11()4()-1()1()19()-5()18()6()-6()]TJ
5.4028 0 Td
[(\n)8( )11()23()]TJ
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[()19()-5()-2()18()-5()2( )11()8()]TJ
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[()-2()18()-6()]TJ
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[()4( )11()]TJ
1.5648 0 Td
[()5()4( )15()-3(")]TJ
ET
Q
q
1 j
1 J
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11.9999 0 0 11.9999 200.0125 600.7181 cm
BT
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1 TL
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1.989 0 Td
(Virosomes)Tj
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(or)Tj
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Q
q
1 j
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BT
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[(\()31( )11()6()1()19()-5()-2()-4()]TJ
3.7076 0 Td
[()-18()-1()6( )11()6( )16()2()]TJ
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[()1(\n)-11(\n)8()-6()-6()]TJ
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[()8()1()13()]TJ
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[()2()1()6()1()-4()2()1()4()-6()]TJ
4.6999 0 Td
[()11()-4()2( )11()]TJ
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[()6( )]TJ
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[()8()3()-4()7()1()2()3()]TJ
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[( )11(\n)]TJ
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[()-5()8()-10()-5()2()6()2()]TJ
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[()12()11()-6()-4()10()]TJ
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[()8()4()]TJ
1.6894 0 Td
[()6()4()1()4( )11()-2()-1()-9()]TJ
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[()6()3()8()8()7()6(")]TJ
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[()-16()5()-5()3()]TJ
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[()8()1()13()]TJ
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[()1()4()-6()5()-5()18()6()-6()]TJ
4.0535 0 Td
[()-3()12()-4()]TJ
1.9502 0 Td
[(\r)-3()1()13( )1()-7( )11()4()2()]TJ
4.388 0 Td
[()1()12()-9( )1()-7( )11()4()2()]TJ
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[( )11()]TJ
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[()18()11()11()13( )11()11()-4()-2()18()6()]TJ
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[()-1( )11()19()-5()13( )6()3(")]TJ
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[()-16()5()-5()3()]TJ
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[()10()1()11()]TJ
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[(\n)8( )11()]TJ
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[(-)]TJ
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[()2()1()]TJ
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[()18()]TJ
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[(1-E)]TJ
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[( )11()]TJ
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[()5()6( )11()13()-6()]TJ
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[()18()]TJ
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[(4;E)]TJ
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[(\n)8( )11()]TJ
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[(\);)]TJ
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[()2()1()]TJ
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[()-7()1()-29(\r)8()-6()]TJ
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[()1()]TJ
1.0035 0 Td
[()-9( )1()2()12()-5()7(\r)8()]TJ
3.2258 0 Td
[()-1( )11()19()-5()13( )6()3()]TJ
3.3845 0 Td
[()8()4()]TJ
1.6894 0 Td
[()5()4( )15()8()-6()]TJ
3.1748 0 Td
[()]TJ
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[()2()1()-6()]TJ
1.9616 0 Td
[()-1()5()-5()]TJ
-34.0892 -1.2983 Td
[()2()-5()18()-4()]TJ
2.381 0 Td
[()18()6()]TJ
1.7008 0 Td
[()-2()18()-6()]TJ
2.211 0 Td
[()4( )11()]TJ
1.5364 0 Td
[()5()4( )15()-3(")]TJ
3.3335 0 Td
[(7)-9()2()5()]TJ
1.8539 0 Td
[()-4()3()8()]TJ
1.9955 0 Td
[(;J)]TJ
1.8992 0 Td
[( )11(\n)]TJ
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[()2()-5()2()]TJ
2.0806 0 Td
[()-1()5()-5()3()]TJ
1.8708 0 Td
[()8()1()13()]TJ
2.058 0 Td
[()2()1()6()-6()-6()6()-6()]TJ
3.4525 0 Td
[()1()]TJ
1.0035 0 Td
[()-4()-5()]TJ
1.1282 0 Td
[()-1()5()-5()]TJ
1.5137 0 Td
[()-2()-1()-9()2()]TJ
2.2337 0 Td
[()8(\n)-7()6()1()]TJ
1.9842 0 Td
[()2()-9( )]TJ
-35.2287 -1.2983 Td
[()5()1()13()]TJ
1.8481 0 Td
[()6( )]TJ
1.0035 0 Td
[()-5()8()-10()-5()2()6()2()2()]TJ
3.4639 0 Td
[()-1( )11()19()-5()8()13()-6()]TJ
4.1329 0 Td
[()6( )]TJ
1.0034 0 Td
[(\()5(0<)]TJ
1.8085 0 Td
[()-5()13()-5()18()6()-6()]TJ
2.914 0 Td
[()-1()5()-5()3()]TJ
1.8652 0 Td
[()1()]TJ
1.0035 0 Td
[()-6()-5()12()10()1()13()]TJ
2.948 0 Td
[()]TJ
0.83 0.64 0.02 0 k
[(<)]TJ
1.4797 0 Td
[(9)17()1()]TJ
0 g
[(")]TJ
1.9729 0 Td
[(,)1()4()]TJ
1.7574 0 Td
[()-9(\r)1()-4()12()-2()18()6()-6()]TJ
3.8948 0 Td
[()-1( )11()4()-1()1()19()-5()18()-5()2( )11()]TJ
5.6353 0 Td
[( )11(\n)]TJ
-36.7311 -1.3039 Td
[(\r)-3()1()13( )1()-7( )11()4()2()]TJ
4.1725 0 Td
[()1()1()]TJ
1.6725 0 Td
[(-)]TJ
0.6916 0 Td
[(B=)-5()]TJ
2.5228 0 Td
[(>)38(')]TJ
1.8595 0 Td
[()8()4()]TJ
1.6895 0 Td
[()-4()2()3()]TJ
1.6441 0 Td
[()1()1()]TJ
1.6667 0 Td
[()-4()4()1()13()1(\n)8( )11()13()]TJ
3.7417 0 Td
[()6()4( )1()-7()1()]TJ
2.931 0 Td
[()1()]TJ
1.0035 0 Td
[()8()]TJ
1.1792 0 Td
[( )11()11()-5()1()3()-4()]TJ
3.2371 0 Td
[()-1( )11()4()-1()1()19()-5()18()-5()2( )11()]TJ
5.6353 0 Td
[(\n)8( )11()]TJ
1.3493 0 Td
[()-4()-5()]TJ
-34.9963 -1.2982 Td
[()5()5()1()-7()-6(.)10()2()1()19()]TJ
4.5807 0 Td
[()2()-9()1()-4()1()4()1()19(")]TJ
5.2101 0 Td
[()-6()-5()2()]TJ
2.2847 0 Td
[()-1()5()-5()3()]TJ
1.8708 0 Td
[()8()1()13()]TJ
2.058 0 Td
[()-4()7()1()18()1()]TJ
2.7892 0 Td
[()2()9()6()12()2()2()-6()]TJ
3.6737 0 Td
[(\n)8( )11()]TJ
1.3436 0 Td
[(\n)-7()1()-10()-4()4()1()]TJ
2.948 0 Td
[(\n)-17()2( )15()]TJ
1.8992 0 Td
[()-18()-1()6( )11()4()1()-5()-29()]TJ
4.1669 0 Td
[()8()3()-4()7()1()-7()2(")]TJ
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 477.0141 cm
BT
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1 TL
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(Uptake)Tj
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3.978 0 Td
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ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 460.0062 cm
BT
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1 TL
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[(6)17()]TJ
1.0941 0 Td
[( )11()13()2()1()]TJ
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[()6( )]TJ
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[()1()23(\r)8()2()5()-5()1()2()18()6()]TJ
4.439 0 Td
[()-7()4()1()-4()4()1()]TJ
3.464 0 Td
[(\r)-3()1()13( )1()-7( )11()4()2()]TJ
4.2689 0 Td
[()8()4()]TJ
1.7178 0 Td
[()1()12()-9( )1()-7( )11()4()2()]TJ
4.2122 0 Td
[()8()13()]TJ
1.44 0 Td
[()-6()-4()10()1()]TJ
2.4095 0 Td
[()12()]TJ
1.2642 0 Td
[()15()]TJ
1.1792 0 Td
[()1()1(\n)-11(\n)8()1()13()1()19()]TJ
3.6283 0 Td
[()-1()5()-5()3()]TJ
1.9219 0 Td
[( )11(\n)]TJ
1.0148 0 Td
[()-4()4()]TJ
-35.4668 -1.2982 Td
[()13()2()5()11()1()18()6( )11()-29()]TJ
4.575 0 Td
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2.0466 0 Td
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1.7235 0 Td
[()6( )]TJ
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[()-1( )11()19()-5()8()13()]TJ
3.6906 0 Td
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2.0977 0 Td
[()7()-3()3()8()2()2()-1()]TJ
4.0365 0 Td
[()1()]TJ
1.0204 0 Td
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2.9311 0 Td
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1.7234 0 Td
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2.3357 0 Td
[()-1( )-6()-5()12()10()1()13()6()]TJ
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1.9219 0 Td
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[()]TJ
0.6576 0 Td
[(\()5(0<)]TJ
1.8368 0 Td
[()-1( )11()19()-5()13( )6()6(")]TJ
3.3165 0 Td
[(9)20( )11()]TJ
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[()-9()1()-4(\n)8( )11()-4()4()-6()]TJ
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1.8936 0 Td
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2.1373 0 Td
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1.6044 0 Td
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1.9219 0 Td
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1.7235 0 Td
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1.8255 0 Td
[($)22('3)]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 446.6834 425.4236 cm
BT
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1 TL
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[(A)]TJ
ET
Q
q
1 j
1 J
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10 0 0 10 453.2031 421.0015 cm
BT
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[()-1()5()-5()3()]TJ
1.9162 0 Td
[(\n)8( )11()]TJ
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[($)22('3)]TJ
ET
Q
q
1 j
1 J
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7.4999 0 0 6.6659 567.3826 425.4236 cm
BT
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1 TL
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ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 408.0188 cm
BT
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1 TL
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[()-1()5()-5()3(")]TJ
2.1373 0 Td
[($)22('3)]TJ
ET
Q
q
1 j
1 J
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7.4999 0 0 6.6659 254.5511 412.4409 cm
BT
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1 TL
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[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 259.4267 408.0188 cm
BT
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1 TL
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[()-1()5()-5()3()]TJ
1.9162 0 Td
[()8()1()13()]TJ
2.0976 0 Td
[(\n)-7()1()-10()-4()4()1()]TJ
3.016 0 Td
[()1()7(\r)-3()2()2()-6()]TJ
3.1805 0 Td
[()1()19()6( )]TJ
1.8255 0 Td
[()-19(<)6()1()-5()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 414.4818 412.4409 cm
BT
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1 TL
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[(A)]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 421.0015 408.0188 cm
BT
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1 TL
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[(\n)8( )11()]TJ
1.7234 0 Td
[(3)9()-19()]TJ
3.9288 0 Td
[()8()4()]TJ
1.7235 0 Td
[()-19(<)6()1()-5()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 529.4551 412.4409 cm
BT
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1 TL
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ET
Q
q
1 j
1 J
0 w
10 0 0 10 534.3307 408.0188 cm
BT
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1 TL
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[(\n)8( )11()]TJ
-33.4316 -1.3039 Td
[(3)14(3C)]TJ
0.83 0.64 0.02 0 k
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[(<&')]TJ
1.8595 0 Td
[(9)17()1()]TJ
0 g
[(")]TJ
2.0183 0 Td
[(3)26( )11()4( )-6()-5()12()10()1()13()2()]TJ
6.1681 0 Td
[()8()1()13()]TJ
2.092 0 Td
[()2()18()6()-6()]TJ
2.3584 0 Td
[(\n)8( )11()]TJ
1.3776 0 Td
[()2()1()8()-6()2()6()]TJ
2.7326 0 Td
[()1()7(\r)8()]TJ
1.6101 0 Td
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1.9162 0 Td
[(\n)8( )6()-5()2( )15()8()-6()]TJ
3.6283 0 Td
[()15()]TJ
1.1792 0 Td
[($)22('3)]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 535.6346 399.4582 cm
BT
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1 TL
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[(A)]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 542.1543 394.9795 cm
BT
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1 TL
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[()-1()5()-5()3()]TJ
1.9218 0 Td
[(\n)8( )11()]TJ
-36.1357 -1.2982 Td
[()1()11()12()-4()4()5()1()-2()-4()]TJ
3.8664 0 Td
[()-1()5()-5()3()]TJ
2.1373 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 282.8976 386.4188 cm
BT
/F6 1 Tf
1 TL
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[(A)]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 289.4173 381.9968 cm
BT
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1 TL
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[()8()4()]TJ
1.7234 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 334.2614 386.4188 cm
BT
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1 TL
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[(A)]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 340.7811 381.9968 cm
BT
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1 TL
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[()2( )11()5()6()2()]TJ
2.931 0 Td
[()-9( )1()2()12()-5()7(\r)8()]TJ
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[()]TJ
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[(<&0)]TJ
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[(9)17()1()]TJ
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[()]TJ
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[()8()4()]TJ
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[(*)]TJ
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Q
q
1 j
1 J
0 w
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BT
/F6 1 Tf
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[(A)]TJ
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Q
q
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1 J
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BT
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[()8()4()]TJ
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[(14)]TJ
ET
Q
q
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BT
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[(A)]TJ
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Q
q
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BT
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[(<&)]TJ
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[(")]TJ
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[()1()1()]TJ
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[( )5()1()-7()1()-29(\r)8()-6()]TJ
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[()-3()18()]TJ
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[()1()]TJ
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[()4( )11()4( )]TJ
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[()-1( )-6()-5()12()10()1()13()]TJ
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[(;";;C)]TJ
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[(9)17()1()]TJ
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[(')]TJ
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[(")]TJ
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[(6)17()19()6()1()13()2()5()]TJ
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[()1()8()-6()7()74()]TJ
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[()8()1()13()]TJ
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[()-6()-4()10()1()]TJ
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[()12()]TJ
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[()15()]TJ
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[()2()2()5()]TJ
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[()1()]TJ
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[()-1( )-6()-5()12()10()1()13()]TJ
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[()-1( )11()19()-5()8()13()-6()]TJ
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[()6( )]TJ
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[()4( )11()4( )-6()-5()12()10()1()13()]TJ
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[()]TJ
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[(;";;C)]TJ
0.83 0.64 0.02 0 k
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[(9)17()1()]TJ
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[(')]TJ
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[(")]TJ
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[(9)20()1()-10()-4()4()1()-4()4( )11()13()6()]TJ
5.5559 0 Td
[()1()]TJ
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[(3)9()-19()]TJ
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[()4( )11()13()]TJ
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[(\r)-3()1()13( )1()-7( )11()4()2()]TJ
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[()-4()3()8()]TJ
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[()1()12()-9( )1()-7( )11()4()2()]TJ
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[()8()1()13()]TJ
2.0977 0 Td
[()-6()-4()10()1()]TJ
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[()12()]TJ
-35.1266 -1.3039 Td
[()-9()1()]TJ
1.5193 0 Td
[()-1()5()-5()]TJ
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[()1()]TJ
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[()4( )11()4( )-6()-5()12()10()1()13()]TJ
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[()1()]TJ
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[()4()-5()1()5()1()13()-6()]TJ
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[()15()]TJ
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[(396)]TJ
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[()]TJ
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(<)Tj
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[(;";;C)]TJ
0.83 0.64 0.02 0 k
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[(9)17()1()]TJ
1.457 0 Td
[(0)]TJ
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[()]TJ
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[()-7()4()1()13()-5()1()]TJ
3.4299 0 Td
[()2()1()-5()2()1(\n)-11()2()-3()8()19()-4()7()]TJ
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[()2()2()5()]TJ
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[(\r)-3()1()13( )]TJ
-35.6595 -1.2982 Td
[()-7( )11()4()2()]TJ
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[()8()1()13()]TJ
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[()-6()-4()10()1()]TJ
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[()12()]TJ
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[()-9()1()]TJ
1.525 0 Td
[()-1()5()-5()]TJ
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[()1()]TJ
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[()-1( )-6()-5()12()10()1()13()]TJ
4.286 0 Td
[()-1( )11()19()-5()8()13()-6()]TJ
4.2122 0 Td
[()6( )]TJ
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[()4( )11()4( )-6()-5()12()10()1()13()]TJ
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[()]TJ
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[(P)]TJ
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[(;";;&C)]TJ
0.83 0.64 0.02 0 k
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[(9)17()1()]TJ
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[(0)]TJ
0 g
[(")]TJ
-32.5187 -1.2983 Td
[(6)17()]TJ
1.0998 0 Td
[()-1( )-6()-5()12()10()1()13()6()]TJ
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[(3)14(3)]TJ
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[()5()4( )15()8()-6()]TJ
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[()2()1()-6()4()1()]TJ
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[()12()11()-6()-4()10()]TJ
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[(\n)-11()13()-6(.)10()2()1()4()-18()]TJ
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[(\n)8( )11()]TJ
1.3776 0 Td
[(\r)-3()1()13( )1()-7( )11()4()2()]TJ
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[()-4()3()8()]TJ
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[()1()12()-9( )1()-7( )11()4()2()]TJ
-30.6535 -1.3039 Td
[()]TJ
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(<)Tj
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[(;";;C)]TJ
0.83 0.64 0.02 0 k
4.2121 0 Td
[(9)17()1()]TJ
1.4627 0 Td
[(')]TJ
0 g
[(")]TJ
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[(<)6()1()2()-5()-2()8()]TJ
3.0728 0 Td
[()6( )]TJ
1.0261 0 Td
[(3)9()-19()]TJ
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[(3)14(3)]TJ
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[()1()]TJ
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[()4( )11()4( )-6()-5()12()10()1()13()2()]TJ
6.0944 0 Td
[()6( )-9( )6()]TJ
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[()12()]TJ
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[()2()1()-5()2()1(\n)-11()2()-3()8()19()-4()7()]TJ
5.0683 0 Td
[()4( )11()13()]TJ
-34.0721 -1.2983 Td
[()1()12()-9( )1()-7( )11()4()2()]TJ
4.2121 0 Td
[()-4()3()8()]TJ
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[()-1( )-6()-5()12()10()1()13()2()]TJ
4.6544 0 Td
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(<)Tj
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[(;";;C)]TJ
0.83 0.64 0.02 0 k
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[(9)17()1()]TJ
1.457 0 Td
[(')]TJ
0 g
[(")]TJ
1.9559 0 Td
[(,)1()4()]TJ
1.7801 0 Td
[()8()4( )11()1()19()]TJ
3.3392 0 Td
[( )11(\n)]TJ
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[()-5()8()-10()-5()2()6()2()2()]TJ
3.5546 0 Td
[()-6()-4()10()1()]TJ
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[()12()]TJ
1.2642 0 Td
[()-9()1()]TJ
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[()-1()5()-5()]TJ
1.559 0 Td
[()1()1()]TJ
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[()2()1()2()-5()-2()8()]TJ
2.9707 0 Td
[()1()]TJ
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[()4( )11()4( )]TJ
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[()8()4()]TJ
1.7178 0 Td
[()-1( )-6()-5()12()10()1()13()6(")]TJ
-7.4493 -1.3039 Td
[(<)6()1()-5()2()1(\n)-11()2()-3()8()19()-4()7()]TJ
5.1759 0 Td
[()4( )11()13()]TJ
2.3131 0 Td
[(1>0)4($)]TJ
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[()-1()5()-5()3()]TJ
1.9162 0 Td
[()1()]TJ
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[()-9( )11()-4()]TJ
2.0523 0 Td
[()4( )11()4( )]TJ
2.931 0 Td
[()8()4()]TJ
1.7178 0 Td
[()-1( )-6()-5()12()10()1()13()]TJ
4.2859 0 Td
[()-3()18()11()10()1()13()-6()]TJ
3.7248 0 Td
[(\r)-3()1()13( )1()-7( )11()4()2()]TJ
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[()-4()3()8()]TJ
2.0296 0 Td
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[()-7( )11()4()2()]TJ
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[()]TJ
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(<)Tj
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[(;";;C)]TJ
0.83 0.64 0.02 0 k
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[(9)17()1()]TJ
1.457 0 Td
[(')]TJ
0 g
[(")]TJ
1.9559 0 Td
[()-16( )11()19()-5()8()13()-6()]TJ
4.4504 0 Td
[()6( )]TJ
1.0204 0 Td
[(\r)-3()1()13( )1()-7( )11()4()]TJ
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[()-1( )]TJ
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[()-6()-5()12()10()1()13()2()]TJ
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[()5()4( )15()8()-6()]TJ
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[()13()-6()12()2()-1()-6()]TJ
3.4016 0 Td
[(\r)-3()1()13( )1()-7( )11()4()]TJ
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[()12()11()-6()-4()10()]TJ
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[()]TJ
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[(P)]TJ
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[(;";&\)C)]TJ
0.83 0.64 0.02 0 k
2.5738 0 Td
[(9)17()1()]TJ
1.4627 0 Td
[(')]TJ
0 g
[(")]TJ
1.9502 0 Td
[(5)-3()-1()2()8()13()1()1()8()]TJ
4.2973 0 Td
[()-5()8()-10()-5()2()6()2()]TJ
3.1918 0 Td
[()12()11()-6()-4()10()]TJ
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[()-9()1()]TJ
-35.0869 -1.3039 Td
[()-1()5()-5()]TJ
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[()]TJ
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[(396)]TJ
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[()1()1()]TJ
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[()2()1()6()-6()-6()6()-6()]TJ
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[(\n)8( )11()]TJ
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[(\r)-3()1()13( )1()-7( )11()4()2()]TJ
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[(;";C)]TJ
0.83 0.64 0.02 0 k
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[(9)17()1()]TJ
1.4626 0 Td
[(0)]TJ
0 g
[(")]TJ
1.8482 0 Td
[(F)47()1()13( )1()-7( )11()4()]TJ
4.1386 0 Td
[()12()11()-6()-4()10()]TJ
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[(;";-)]TJ
3.855 0 Td
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[(396)]TJ
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[(;";)]TJ
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[()1()]TJ
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[(1>0)4($)]TJ
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[()4( )11()4( )-6()-5()12()10()1()13()]TJ
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[()-4()3()8()]TJ
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[(\()5(>8$)]TJ
3.5093 0 Td
[()4( )11()4( )-6()-5()12()10()1()13()]TJ
5.7203 0 Td
[()]TJ
0.83 0.64 0.02 0 k
[(9)17()1()]TJ
1.8085 0 Td
[()]TJ
0 g
[(")]TJ
-21.7075 -1.2983 Td
[(>)39()1()3()8()]TJ
3.2994 0 Td
[()1()11()12()-4()4()5()1()-2()-4()]TJ
3.8664 0 Td
[()11()13( )1()7()1()2()12()6( )11()]TJ
4.4561 0 Td
[()-1()5()-5()3()]TJ
1.9162 0 Td
[($)22('3)]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 383.9811 152.4472 cm
BT
/F6 1 Tf
1 TL
0 0 Td
[(A)]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 388.2897 148.0251 cm
BT
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1 TL
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[()]TJ
0.5612 0 Td
[()1()19()6()1()-4()3()-4()1(/)-2()-6()]TJ
4.9549 0 Td
[()4( )11()13()]TJ
2.3188 0 Td
[(\r)-3()1()13( )1()-7( )11()4()2()]TJ
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[()-4()3()8()]TJ
2.0353 0 Td
[()1()12()-9( )1()-7( )11()4()2()]TJ
-32.9609 -1.3039 Td
[()2()-1()-1( )11()13()1()1()8()]TJ
4.1385 0 Td
[()6( )]TJ
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[(396)]TJ
1.9559 0 Td
[()]TJ
0.83 0.64 0.02 0 k
[(9)17()1()]TJ
1.8085 0 Td
[(0)]TJ
0 g
[(")]TJ
1.8482 0 Td
[(0)-19( )11()-4()]TJ
2.1373 0 Td
[(\r)-3()1()13( )1()-7( )11()4()2()]TJ
4.2633 0 Td
[()8()4()]TJ
1.7234 0 Td
[()1()12()-9( )1()-7( )11()4()2()]TJ
4.2122 0 Td
[()8()1()13()]TJ
2.0976 0 Td
[()-6()-4()10()1()]TJ
2.4095 0 Td
[()12()]TJ
1.2642 0 Td
[()15()]TJ
1.1792 0 Td
[($)22('3)]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 533.7637 139.4645 cm
BT
/F6 1 Tf
1 TL
0 0 Td
[(A)]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 540.2834 134.9858 cm
BT
/F6 1 Tf
1 TL
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[()-1()5()-5()3()]TJ
-34.0268 -1.2982 Td
[()-3()12()-4()]TJ
1.9899 0 Td
[()]TJ
0.6576 0 Td
[()19()2()6()]TJ
2.5058 0 Td
[()2()1()-6()4()1()]TJ
2.7836 0 Td
[()1(\n)-11(\n)-11()2()-3()2()-18()]TJ
3.2145 0 Td
[()-4()3()8()]TJ
2.0353 0 Td
[()15()]TJ
1.1792 0 Td
[(1>0)4($)]TJ
3.084 0 Td
[( )11()]TJ
1.0885 0 Td
[(\()5(>8$)]TJ
3.8665 0 Td
[()]TJ
/F13 1 Tf
(<)Tj
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[(;";;C)]TJ
0.83 0.64 0.02 0 k
4.2122 0 Td
[(9)17()1()]TJ
1.4627 0 Td
[()]TJ
0 g
[(")]TJ
1.2642 0 Td
[(3)16()18()6()6()4()-6()]TJ
3.7304 0 Td
[($)22('3)]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 563.9244 126.4251 cm
BT
/F6 1 Tf
1 TL
0 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 109.0204 cm
BT
/F6 1 Tf
1 TL
0 0 Td
[()-1()5()-5()3()]TJ
1.9162 0 Td
[()6( )-9( )6()]TJ
2.0182 0 Td
[()12()]TJ
1.2586 0 Td
[()-9( )11()-4()]TJ
2.0579 0 Td
[(\r)-3()1()13( )1()-7( )11()4()2()]TJ
4.2633 0 Td
[()8()4()]TJ
1.7235 0 Td
[()1()12()-9( )1()-7( )11()4()2()]TJ
4.2122 0 Td
[()5()2()-1()-1()2()5()2(\n)-7()-5()-5()7()]TJ
4.8586 0 Td
[()]TJ
0.83 0.64 0.02 0 k
[(<\))]TJ
1.5137 0 Td
[(9)17()1()]TJ
0 g
[(")]TJ
-22.626 -1.3039 Td
[(\()22()8()-10()-5()2()6()2()]TJ
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