Current in vitro approaches to assess nanoparticle interactions with lung cells.

Fytianos, Kleanthis; Drasler, Barbara; Blank, Fabian; Von Garnier, Christophe; Seydoux, Emilie; Rodriguez-Lorenzo, Laura; Petri-Fink, Alke; Rothen-Rutishauser, Barbara (2016). Current in vitro approaches to assess nanoparticle interactions with lung cells. Nanomedicine, 11(18), pp. 2457-2469. Future Medicine 10.2217/nnm-2016-0199

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The respiratory tract is in constant contact with inhaled antigens from the external environment. In order to shape its line of defense, it is populated by various types of immune cells. Taking into account the scientific breakthroughs of nanomedicine and nanoparticle drug delivery, we can think of the respiratory tract as an ideal target organ to study and develop nanocarrier-based vaccines to treat respiratory tract disorders. Nanoparticles have been proven capable of specific cell targeting and, when suitably engineered, are able to induce an immunomodulatory effect. The aim of this review is to highlight in vitro approaches to the study of nanoparticle-lung immune cell interactions and recent advances in the targeting of immune cells using nanoparticle-based systems.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Mu50 > Forschungsgruppe Pneumologie (Erwachsene)
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Pneumology

UniBE Contributor:

Blank, Fabian; Von Garnier, Christophe and Seydoux, Emilie

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1748-6963

Publisher:

Future Medicine

Language:

English

Submitter:

Rahel Holderegger

Date Deposited:

23 Mar 2017 16:23

Last Modified:

22 Jan 2019 10:48

Publisher DOI:

10.2217/nnm-2016-0199

PubMed ID:

27529369

Additional Information:

Emilie Seydoux has contributed to this article even after leaving us by the end of 2015, when she terminated her education as doctoral candidate.

Uncontrolled Keywords:

biomedical nanoparticles; immune modulation; in vitro approaches; lung immune cells; specific targeting

BORIS DOI:

10.7892/boris.93260

URI:

https://boris.unibe.ch/id/eprint/93260

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