Community-acquired Haemophilus influenzae pneumonia--New insights from the CAPNETZ study.

Forstner, Christina; Rohde, Gernot; Rupp, Jan; Schuette, Hartwig; Ott, Sebastian Robert; Hagel, Stefan; Harrison, Nicole; Thalhammer, Florian; von Baum, Heike; Suttorp, Norbert; Welte, Tobias; Pletz, Mathias W (2016). Community-acquired Haemophilus influenzae pneumonia--New insights from the CAPNETZ study. Journal of infection, 72(5), pp. 554-563. Elsevier 10.1016/j.jinf.2016.02.010

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OBJECTIVES We aimed to identify clinical characteristics and to assess effectiveness of different initial antibiotic regimens in adult patients with community-acquired pneumonia (CAP) caused by Haemophilus influenzae. METHODS Characteristics were compared between patients with H. influenzae monoinfection versus CAP of other and unknown aetiology enrolled by the German prospective cohort study CAPNETZ. Impact of initial antibiotic treatment on "early clinical response" according to FDA criteria and overall clinical cure were analysed. RESULTS H. influenzae was found in 176 out of 2790 patients with pathogen detection (6.3%). Characteristics significantly associated with a H. influenzae CAP (p < 0.017) included purulent sputum, prior pneumococcal vaccination and respiratory co-morbidities. Early clinical response rates on day 4 did not differ between patients receiving any mono- versus combination therapy (85.9% versus 88%), but were numerically higher for regimens including any fluoroquinolone (96.7%) and lower under macrolide monotherapy (70%). Initial CURB-65 score and chronic liver disease were identified as negative predictors for "early clinical response". At day 14, overall clinical cure was 91.9%. CONCLUSIONS H. influenzae was a common CAP pathogen, particularly in patients with previous pneumococcal vaccination and respiratory co-morbidities. Severity of illness and chronic liver disease were associated with a lower rate of "early clinical response".

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Pneumology

UniBE Contributor:

Ott, Sebastian Robert


600 Technology > 610 Medicine & health








Rahel Holderegger

Date Deposited:

29 Mar 2017 12:18

Last Modified:

05 Sep 2017 14:08

Publisher DOI:


PubMed ID:


Web of Science ID:


Uncontrolled Keywords:

Beta-lactams; CURB-65 score; Fluoroquinolones; Haemophilus influenzae; Macrolides; Respiratory tract infection




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