The Flexibility of Ectopic Lipids.

Loher, Hannah; Kreis, Roland; Boesch, Christoph Hans; Christ, Emanuel (2016). The Flexibility of Ectopic Lipids. International journal of molecular sciences, 17(9) Molecular Diversity Preservation International MDPI 10.3390/ijms17091554

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In addition to the subcutaneous and the visceral fat tissue, lipids can also be stored in non-adipose tissue such as in hepatocytes (intrahepatocellular lipids; IHCL), skeletal (intramyocellular lipids; IMCL) or cardiac muscle cells (intracardiomyocellular lipids; ICCL). Ectopic lipids are flexible fuel stores that can be depleted by physical exercise and repleted by diet. They are related to obesity and insulin resistance. Quantification of IMCL was initially performed invasively, using muscle biopsies with biochemical and/or histological analysis. ¹H-magnetic resonance spectroscopy (¹H-MRS) is now a validated method that allows for not only quantifying IMCL non-invasively and repeatedly, but also assessing IHCL and ICCL. This review summarizes the current available knowledge on the flexibility of ectopic lipids. The available evidence suggests a complex interplay between quantitative and qualitative diet, fat availability (fat mass), insulin action, and physical exercise, all important factors that influence the flexibility of ectopic lipids. Furthermore, the time frame of the intervention on these parameters (short-term vs. long-term) appears to be critical. Consequently, standardization of physical activity and diet are critical when assessing ectopic lipids in predefined clinical situations.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology > DCR Magnetic Resonance Spectroscopy and Methodology (AMSM)

UniBE Contributor:

Loher, Hannah; Kreis, Roland; Boesch, Christoph Hans and Christ, Emanuel

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1661-6596

Publisher:

Molecular Diversity Preservation International MDPI

Language:

English

Submitter:

Christoph Hans Boesch

Date Deposited:

29 Mar 2017 12:26

Last Modified:

29 Mar 2017 20:58

Publisher DOI:

10.3390/ijms17091554

PubMed ID:

27649157

Uncontrolled Keywords:

athlete’s paradox; diabetes mellitus; ectopic lipids; exercise; fasting; growth hormone deficiency; insulin resistance; intracardiomyocellular lipids; intrahepatocellular lipids; intramyocellular lipids

BORIS DOI:

10.7892/boris.93291

URI:

https://boris.unibe.ch/id/eprint/93291

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