RNA Editing-Systemic Relevance and Clue to Disease Mechanisms?

Meier, Jochen C; Kankowski, Svenja; Krestel, Heinz Eric; Hetsch, Florian (2016). RNA Editing-Systemic Relevance and Clue to Disease Mechanisms? Frontiers in molecular neuroscience, 9(124), p. 124. Frontiers Research Foundation 10.3389/fnmol.2016.00124

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Recent advances in sequencing technologies led to the identification of a plethora of different genes and several hundreds of amino acid recoding edited positions. Changes in editing rates of some of these positions were associated with diseases such as atherosclerosis, myopathy, epilepsy, major depression disorder, schizophrenia and other mental disorders as well as cancer and brain tumors. This review article summarizes our current knowledge on that front and presents glycine receptor C-to-U RNA editing as a first example of disease-associated increased RNA editing that includes assessment of disease mechanisms of the corresponding gene product in an animal model.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Krestel, Heinz Eric

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1662-5099

Publisher:

Frontiers Research Foundation

Language:

English

Submitter:

Stefanie Hetzenecker

Date Deposited:

29 Mar 2017 14:35

Last Modified:

02 Apr 2017 02:18

Publisher DOI:

10.3389/fnmol.2016.00124

PubMed ID:

27932948

Uncontrolled Keywords:

RNA editing; cancer; epilepsy; glutamate receptor; glycine receptor; mental disorders; potassium channels; serotonin

BORIS DOI:

10.7892/boris.93342

URI:

https://boris.unibe.ch/id/eprint/93342

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