Abnormalities of brain neural circuits related to obesity: A Diffusion Tensor Imaging study.

Papageorgiou, Ioannis; Astrakas, Loukas G; Xydis, Vassileios; Alexiou, George A; Bargiotas, Panagiotis; Tzarouchi, Loukia; Zikou, Anastasia K; Kiortsis, Dimitrios N; Argyropoulou, Maria I (2017). Abnormalities of brain neural circuits related to obesity: A Diffusion Tensor Imaging study. Magnetic resonance imaging, 37, pp. 116-121. Elsevier 10.1016/j.mri.2016.11.018

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PURPOSE Increased Body-Mass-Index (BMI) has been associated with brain atrophy in both gray and white matter structures. However, little is known concerning the integrity of white matter tracts in obesity. The purpose of the study was to evaluate the pattern of changes in white matter microstructure in human adiposity. MATERIAL AND METHODS The study included 268 participants (52 obese, 96 overweight and 120 normal-weight) that were retrospectively evaluated by Diffusion Tensor Imaging. The fractional anisotropy, axial, radial and mean diffusivity values were compared between the above groups using Tract Based Spatial Statistics. RESULTS The analysis revealed that the increased BMI was related with decreased fractional anisotropy in several white matter regions including the anterior and posterior thalamic radiation, the inferior fronto-occipital fasciculus, the inferior and superior longitudinal fasciculus, the corpus callosum (callosal body and forceps minor), the uncinate fasciculus, the internal capsule, the corticospinal tract and the cingulum (cingulate gyrus and hippocampus). CONCLUSIONS Anisotropic diffusion of anatomic regions governing important brain circuits such as reward seeking inhibition, motivation/drive and learning/conditioning decreases with increasing BMI.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Bargiotas, Panagiotis

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0730-725X

Publisher:

Elsevier

Language:

English

Submitter:

Stefanie Hetzenecker

Date Deposited:

29 Mar 2017 14:50

Last Modified:

30 Mar 2017 13:17

Publisher DOI:

10.1016/j.mri.2016.11.018

PubMed ID:

27899333

Uncontrolled Keywords:

Body-Mass-Index; Food addiction; Fractional anisotropy; Reward system

BORIS DOI:

10.7892/boris.93353

URI:

https://boris.unibe.ch/id/eprint/93353

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