Lethal toxin of Clostridium sordellii is associated with fatal equine atypical myopathy

Unger, Lucia; Straub, Reto; Lehmann, Andrea D; Graber, Franziska; Stahl, Christina; Frey, Joachim; Gerber, Vinzenz; Hoppeler, Hans; Baum, Oliver (2010). Lethal toxin of Clostridium sordellii is associated with fatal equine atypical myopathy. Veterinary microbiology, 144(3-4), pp. 487-92. Amsterdam: Elsevier 10.1016/j.vetmic.2010.01.024

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The lethal toxin of Clostridium sordellii (TcsL) evokes severe, mostly fatal disease patterns like toxic shock syndrome in humans and animals. Since this large clostridial toxin-induced severe muscle damaging when injected intramuscularly into mice, we hypothesized that TcsL is also associated with equine atypical myopathy (EAM), a fatal myodystrophy of hitherto unknown etiology. Transmission electron microscopy revealed skeletal and heart muscles of EAM-affected horses to undergo degeneration ultrastructurally similar to the damage found in TcsL-treated mice. Performing immunohistochemistry, myofibers of EAM-affected horses specifically reacted with sera derived from horses with EAM as well as an antibody specific for the N-terminal part of TcsL, while both antibodies failed to bind to the myofibers of either healthy horses or those with other myopathies. The presence of TcsL in myofibers of horses with EAM suggests that it plays a role as trigger or even as lethal factor in this disease.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Experimental Clinical Research
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Equine Clinic
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Veterinary Bacteriology
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Functional Anatomy

UniBE Contributor:

Unger, Lucia; Straub, Reto; Frey, Joachim; Gerber, Vinzenz; Hoppeler, Hans-Heinrich and Baum, Oliver

ISSN:

0378-1135

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:09

Last Modified:

11 Sep 2014 21:22

Publisher DOI:

10.1016/j.vetmic.2010.01.024

PubMed ID:

20189733

Web of Science ID:

000281358600035

URI:

https://boris.unibe.ch/id/eprint/934 (FactScience: 201531)

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