Role of Radiotherapy in Aggressive Digital Papillary Adenocarcinoma.

Feldmeyer, Laurence; Prieto, Victor G; Ivan, Doina; Nagarajan, Priyadharsini; Tetzlaff, Michael T; Curry, Jonathan L; Bell, Diana; Moon, Bryan S; Torres-Cabala, Carlos A; Aung, Phyu P (2016). Role of Radiotherapy in Aggressive Digital Papillary Adenocarcinoma. Annals of clinical and laboratory science, 46(2), pp. 222-224. Association of Clinical Scientists

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Aggressive digital papillary adenocarcinoma (ADPA) is a rare and often misdiagnosed malignant tumor of the sweat glands, most commonly encountered on the extremities. Due to the relatively high metastatic potential of the tumor, aggressive surgical treatment, including amputation, is generally recommended. We present a case of a 36-year-old male with an over 10-year history of a skin lesion on the right hand in the web space between the index and the middle finger. Histologically, the lesion revealed a malignant epithelioid neoplasm with features consistent with ADPA. The lesion was treated with 5-weeks preoperative radiation (total 5000 cGy) followed by surgical resection. There was no evidence of residual disease confirmed by pathological study of re-excision specimen as well as imaging studies. This is, to the best of knowledge, the first report of complete regression of an ADPA after radiotherapy.

Item Type:

Journal Article (Further Contribution)


04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology

UniBE Contributor:

Feldmeyer, Laurence


600 Technology > 610 Medicine & health




Association of Clinical Scientists




Sandra Nyffenegger

Date Deposited:

01 Mar 2017 09:51

Last Modified:

01 Mar 2017 09:51

PubMed ID:


Uncontrolled Keywords:

Aggressive digital papillary adenocarcinoma; fine needle aspiration biopsy; radiotherapy


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