IgE and FcεRI are highly expressed on innate cells in psoriasis.

Yan, K-X; Huang, Q; Fang, X; Zhang, Z-H; Han, L; Gadaldi, Karolina; Kang, K-F; Zheng, Z-Z; Xu, J-H; Yawalkar, Nikhil (2016). IgE and FcεRI are highly expressed on innate cells in psoriasis. British journal of dermatology, 175(1), pp. 122-133. Wiley-Blackwell 10.1111/bjd.14459

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BACKGROUND Although elevated serum IgE levels have been reported in psoriasis, the role of IgE in psoriasis still needs to be clarified. OBJECTIVES To analyse serum total IgE levels in addition to the presence and distribution of IgE and FcεRI in psoriatic lesions, and to investigate alteration of IgE and FcεRI after successful systemic treatment. METHODS Total serum IgE levels were determined using enzyme-linked immunosorbent assay. The expression and localization of IgE and FcεRI was investigated using immunohistochemistry and double immunofluorescence. RESULTS Elevated total serum IgE levels were found in 39% of patients with psoriasis. The levels of total serum IgE were significantly higher in male patients compared with female patients. Furthermore, total serum IgE levels decreased after successful systemic treatment. A positive correlation between IgE+ and FcεRI+ cells and a significant increase of these cells was found in psoriatic lesions when compared with normal skin. Interestingly, IgE+ and FcεRI+ cells decreased significantly after successful therapy with ustekinumab. IgE and FcεRI were coexpressed on mast cells, epidermal Langerhans cells, dermal dendritic cells, macrophages and a small number of neutrophils. CONCLUSIONS IgE might participate in the development of psoriasis by activating FcεRI-bearing cells.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology

UniBE Contributor:

Gadaldi, Karolina and Yawalkar, Nikhil

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0007-0963

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Sandra Nyffenegger

Date Deposited:

28 Feb 2017 10:16

Last Modified:

28 Feb 2017 10:16

Publisher DOI:

10.1111/bjd.14459

PubMed ID:

26853903

BORIS DOI:

10.7892/boris.93492

URI:

https://boris.unibe.ch/id/eprint/93492

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