Blebbing confers resistance against cell lysis

Babiychuk, E B; Monastyrskaya, K; Potez, S; Draeger, A (2011). Blebbing confers resistance against cell lysis. Cell death and differentiation, 18(1), pp. 80-9. Basingstoke: Nature Publishing Group 10.1038/cdd.2010.81

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The plasma membrane constitutes a barrier that maintains the essential differences between the cytosol and the extracellular environment. Plasmalemmal injury is a common event during the life of many cells that often leads to their premature, necrotic death. Blebbing - a display of plasmalemmal protrusions - is a characteristic feature of injured cells. In this study, we disclose a previously unknown role for blebbing in furnishing resistance to plasmalemmal injury. Blebs serve as precursors for injury-induced intracellular compartments that trap damaged segments of the plasma membrane. Hence, loss of cytosol and the detrimental influx of extracellular constituents are confined to blebs that are sealed off from the cell body by plugs of annexin A1 - a Ca(2+)- and membrane-binding protein. Our findings shed light on a fundamental process that contributes to the survival of injured cells. By targeting annexin A1/blebbing, new therapeutic approaches could be developed to avert the necrotic loss of cells in a variety of human pathologies.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Cell Biology
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy

UniBE Contributor:

Babiychuk, Eduard; Monastyrskaya-Stäuber, Katia; Potez, Sarah and Draeger, Annette

ISSN:

1350-9047

Publisher:

Nature Publishing Group

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:09

Last Modified:

06 Dec 2013 13:20

Publisher DOI:

10.1038/cdd.2010.81

PubMed ID:

20596076

Web of Science ID:

000285289900010

URI:

https://boris.unibe.ch/id/eprint/935 (FactScience: 201532)

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