Alpha-PET with terbium-149: evidence and perspectives for radiotheragnostics

Müller, Cristina; Vermeulen, Christiaan; Köster, Ulli; Johnston, Karl; Türler, Andreas; Schibli, Roger; van der Meulen, Nicholas P. (2016). Alpha-PET with terbium-149: evidence and perspectives for radiotheragnostics. EJNMMI Radiopharmacy and Chemistry, 1(1), p. 5. Springer 10.1186/s41181-016-0008-2

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149Tb represents a powerful alternative to currently used α-emitters: the relatively short half-life (T1/2 = 4.1 h), low α-energy (3.97 MeV, Iα = 16.7 %), absence of α-emitting daughters and stable coordination via DOTA are favorable features for potential clinical application. In this letter, we wish to highlight the unique characteristics of 149Tb for PET imaging, based on its positron emission (Eβ+mean = 730 keV, Iβ+ = 7.1 %) in addition to it’s a therapeutic value. To this end, a preclinical study with a tumor-bearing mouse is presented. The perspective of alpha-PET makes 149Tb highly appealing for radiotheragnostic applications in future clinical trials.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

10 Strategic Research Centers > Albert Einstein Center for Fundamental Physics (AEC)
08 Faculty of Science > Physics Institute > Laboratory for High Energy Physics (LHEP)
08 Faculty of Science > Departement of Chemistry and Biochemistry

UniBE Contributor:

Türler, Andreas and Schibli, Roger

Subjects:

500 Science > 530 Physics
500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry

ISSN:

2365-421X

Publisher:

Springer

Language:

English

Submitter:

Franziska Bornhauser-Rufer

Date Deposited:

24 Jan 2017 09:44

Last Modified:

24 Jan 2017 09:44

Publisher DOI:

10.1186/s41181-016-0008-2

BORIS DOI:

10.7892/boris.93777

URI:

https://boris.unibe.ch/id/eprint/93777

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