Imaging quality of 44Sc in comparison with five other PET radionuclides using Derenzo phantoms and preclinical PET

Bunka, Maruta; Müller, Cristina; Vermeulen, Christiaan; Haller, Stephanie; Türler, Andreas; Schibli, Roger; van der Meulen, Nicholas P. (2016). Imaging quality of 44Sc in comparison with five other PET radionuclides using Derenzo phantoms and preclinical PET. Applied radiation and isotopes, 110, pp. 129-133. Elsevier 10.1016/j.apradiso.2016.01.006

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PET is the favored nuclear imaging technique because of the high sensitivity and resolution it provides, as well as the possibility for quantification of accumulated radioactivity. 44Sc (T1/2=3.97 h, Eβ+=632 keV) was recently proposed as a potentially interesting radionuclide for PET. The aim of this study was to investigate the image quality, which can be obtained with 44Sc, and compare it with five other, frequently employed PET nuclides using Derenzo phantoms and a small-animal PET scanner. The radionuclides were produced at the medical cyclotron at CRS, ETH Zurich (11C, 18F), at the Injector II research cyclotron at CRS, PSI (64Cu, 89Zr, 44Sc), as well as via a generator system (68Ga). Derenzo phantoms, containing solutions of each of these radionuclides, were scanned using a GE Healthcare eXplore VISTA small-animal PET scanner. The image resolution was determined for each nuclide by analysis of the intensity signal using the reconstructed PET data of a hole diameter of 1.3 mm. The image quality of 44Sc was compared to five frequently-used PET radionuclides. In agreement with the positron range, an increasing relative resolution was determined in the sequence of 68Ga<44Sc<89Zr<11C<64Cu<18F. The performance of 44Sc was in agreement with the theoretical expectations based on the energy of the emitted positrons.

Item Type:

Journal Article (Original Article)

Division/Institute:

10 Strategic Research Centers > Albert Einstein Center for Fundamental Physics (AEC)
08 Faculty of Science > Physics Institute > Laboratory for High Energy Physics (LHEP)
08 Faculty of Science > Departement of Chemistry and Biochemistry

UniBE Contributor:

Bunka, Maruta; Türler, Andreas and Schibli, Roger

Subjects:

500 Science > 530 Physics
500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry

ISSN:

0969-8043

Publisher:

Elsevier

Language:

English

Submitter:

Franziska Bornhauser-Rufer

Date Deposited:

24 Jan 2017 09:18

Last Modified:

24 Jan 2017 09:18

Publisher DOI:

10.1016/j.apradiso.2016.01.006

BORIS DOI:

10.7892/boris.93791

URI:

https://boris.unibe.ch/id/eprint/93791

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