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0.935 0.923 1.021 0.933 1.107 0.933 c
1.236 0.937 1.365 0.926 1.491 0.898 c
1.491 0.47 l
1.378 0.49 l
1.238 0.49 l
1.171 0.492 1.106 0.474 1.049 0.439 c
0.99 0.388 0.96 0.311 0.97 0.233 c
0.97 0 l
1.437 0 l
1.437 -0.408 l
0.957 -0.408 l
0.957 -2.465 l
0.408 -2.465 l
0.408 -0.408 l
0 -0.408 l
h
f
1 0 0 1 2.9074 -2.1326 cm
0 0 m
0.107 -0.001 0.212 0.025 0.305 0.075 c
0.392 0.126 0.467 0.195 0.525 0.278 c
0.583 0.363 0.626 0.458 0.651 0.559 c
0.706 0.768 0.706 0.987 0.651 1.197 c
0.627 1.297 0.584 1.393 0.525 1.478 c
0.467 1.559 0.392 1.627 0.305 1.677 c
0.106 1.78 -0.13 1.78 -0.329 1.677 c
-0.416 1.627 -0.491 1.559 -0.549 1.478 c
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-0.238 0.018 -0.119 -0.008 0 0 c
0 -0.432 m
-0.182 -0.435 -0.363 -0.401 -0.531 -0.333 c
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-1.035 0.057 -1.117 0.197 -1.169 0.35 c
-1.227 0.52 -1.256 0.698 -1.255 0.878 c
-1.256 1.056 -1.227 1.234 -1.169 1.402 c
-1.118 1.556 -1.035 1.697 -0.926 1.817 c
-0.815 1.934 -0.681 2.027 -0.531 2.088 c
-0.19 2.219 0.187 2.219 0.528 2.088 c
0.677 2.027 0.812 1.934 0.922 1.817 c
1.031 1.697 1.114 1.556 1.166 1.402 c
1.223 1.233 1.25 1.056 1.248 0.878 c
1.25 0.698 1.223 0.52 1.166 0.35 c
1.114 0.197 1.031 0.057 0.922 -0.062 c
0.812 -0.179 0.677 -0.272 0.528 -0.333 c
0.36 -0.401 0.181 -0.434 0 -0.432 c
f
1 0 0 1 1.6971 2.1326 cm
0 0 m
0.514 0 l
0.514 -0.48 l
0.532 -0.409 0.563 -0.343 0.607 -0.285 c
0.655 -0.219 0.711 -0.16 0.775 -0.11 c
0.845 -0.062 0.923 -0.025 1.005 0 c
1.082 0.032 1.165 0.048 1.248 0.048 c
1.389 0.048 l
1.464 0.048 l
1.464 -0.48 l
1.347 -0.48 l
1.231 -0.48 l
1.141 -0.479 1.052 -0.498 0.97 -0.535 c
0.888 -0.573 0.815 -0.629 0.758 -0.699 c
0.693 -0.779 0.644 -0.869 0.614 -0.967 c
0.577 -1.084 0.56 -1.207 0.562 -1.33 c
0.562 -2.51 l
0.014 -2.51 l
0.014 0 l
h
f
1 0 0 1 -15.9154 -6.9531 cm
0 0 m
-0.525 0 l
-0.525 0.343 l
-0.593 0.216 -0.696 0.111 -0.823 0.041 c
-0.946 -0.032 -1.085 -0.07 -1.227 -0.072 c
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-2.098 0.38 -2.176 0.639 -2.157 0.902 c
-2.157 2.496 l
-1.608 2.496 l
-1.608 0.974 l
-1.623 0.811 -1.579 0.648 -1.485 0.514 c
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-1.049 0.374 -0.955 0.387 -0.867 0.418 c
-0.794 0.45 -0.73 0.498 -0.679 0.559 c
-0.629 0.621 -0.594 0.694 -0.576 0.771 c
-0.555 0.859 -0.544 0.949 -0.545 1.039 c
-0.545 2.496 l
0.003 2.496 l
0.003 0.014 l
h
f
1 0 0 1 2.5029 1.2514 cm
0 0 m
0.001 0.116 -0.014 0.231 -0.045 0.343 c
-0.071 0.444 -0.115 0.539 -0.175 0.624 c
-0.232 0.704 -0.306 0.77 -0.391 0.819 c
-0.482 0.871 -0.585 0.897 -0.689 0.895 c
-0.892 0.908 -1.088 0.818 -1.21 0.655 c
-1.335 0.466 -1.396 0.243 -1.385 0.017 c
-1.386 -0.099 -1.371 -0.214 -1.341 -0.326 c
-1.313 -0.425 -1.267 -0.518 -1.203 -0.6 c
-1.143 -0.688 -1.064 -0.761 -0.97 -0.813 c
-0.879 -0.859 -0.778 -0.883 -0.675 -0.881 c
-0.569 -0.885 -0.464 -0.862 -0.37 -0.813 c
-0.286 -0.763 -0.213 -0.695 -0.158 -0.614 c
-0.1 -0.53 -0.06 -0.435 -0.038 -0.336 c
-0.013 -0.23 0 -0.122 0 -0.014 c
h
-1.91 1.245 m
-1.392 1.245 l
-1.392 0.902 l
-1.322 1.037 -1.209 1.146 -1.07 1.21 c
-0.929 1.273 -0.778 1.304 -0.624 1.303 c
-0.448 1.307 -0.274 1.272 -0.113 1.2 c
0.028 1.134 0.152 1.036 0.25 0.915 c
0.349 0.79 0.422 0.647 0.466 0.494 c
0.515 0.327 0.54 0.154 0.538 -0.021 c
0.538 -0.184 0.516 -0.347 0.473 -0.504 c
0.434 -0.653 0.368 -0.794 0.278 -0.919 c
0.187 -1.04 0.07 -1.139 -0.065 -1.207 c
-0.212 -1.283 -0.376 -1.32 -0.542 -1.317 c
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-1.371 -2.184 l
-1.92 -2.184 l
-1.92 1.245 l
h
f
1 0 0 1 1.4297 -0.0377 cm
0 0 m
0 -0.105 0.014 -0.21 0.041 -0.312 c
0.065 -0.41 0.107 -0.503 0.165 -0.586 c
0.22 -0.666 0.292 -0.732 0.377 -0.778 c
0.572 -0.877 0.803 -0.877 0.998 -0.778 c
1.084 -0.729 1.158 -0.659 1.214 -0.576 c
1.27 -0.49 1.312 -0.395 1.337 -0.295 c
1.363 -0.188 1.374 -0.079 1.371 0.031 c
1.385 0.261 1.32 0.488 1.186 0.675 c
1.065 0.826 0.879 0.91 0.686 0.902 c
0.572 0.906 0.459 0.879 0.36 0.823 c
0.273 0.772 0.199 0.701 0.144 0.617 c
0.087 0.529 0.046 0.432 0.024 0.329 c
0.004 0.221 -0.004 0.11 0 0 c
1.917 -1.214 m
1.395 -1.214 l
1.395 -0.871 l
1.328 -1.009 1.214 -1.118 1.073 -1.179 c
0.933 -1.241 0.781 -1.273 0.627 -1.272 c
0.452 -1.276 0.277 -1.241 0.117 -1.169 c
-0.024 -1.104 -0.148 -1.008 -0.247 -0.888 c
-0.346 -0.763 -0.42 -0.62 -0.463 -0.466 c
-0.512 -0.297 -0.536 -0.121 -0.535 0.055 c
-0.539 0.252 -0.507 0.448 -0.442 0.634 c
-0.389 0.784 -0.307 0.922 -0.199 1.039 c
-0.104 1.141 0.014 1.221 0.144 1.272 c
0.271 1.322 0.406 1.347 0.542 1.347 c
0.621 1.348 0.7 1.341 0.778 1.327 c
0.857 1.313 0.934 1.29 1.008 1.258 c
1.081 1.226 1.149 1.185 1.21 1.135 c
1.276 1.08 1.33 1.014 1.371 0.939 c
1.371 2.208 l
1.92 2.208 l
1.92 -1.221 l
h
f
1 0 0 1 4.0388 0.024 cm
0 0 m
-0.094 -0.057 -0.199 -0.092 -0.309 -0.099 c
-0.43 -0.099 -0.551 -0.117 -0.672 -0.151 c
-0.729 -0.16 -0.785 -0.174 -0.84 -0.192 c
-0.891 -0.208 -0.94 -0.232 -0.984 -0.264 c
-1.027 -0.295 -1.061 -0.336 -1.083 -0.384 c
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-1.124 -0.622 -1.105 -0.677 -1.07 -0.72 c
-1.035 -0.762 -0.992 -0.796 -0.943 -0.819 c
-0.891 -0.845 -0.836 -0.862 -0.778 -0.871 c
-0.725 -0.875 -0.671 -0.875 -0.617 -0.871 c
-0.551 -0.87 -0.486 -0.862 -0.422 -0.847 c
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-0.16 -0.727 -0.107 -0.677 -0.065 -0.617 c
-0.022 -0.552 0 -0.476 -0.003 -0.398 c
-0.003 0.007 l
h
0.549 -0.686 m
0.545 -0.735 0.555 -0.785 0.576 -0.83 c
0.6 -0.862 0.639 -0.879 0.679 -0.874 c
0.737 -0.874 l
0.813 -0.874 l
0.813 -1.255 l
0.737 -1.275 l
0.645 -1.296 l
0.549 -1.296 l
0.47 -1.296 l
0.373 -1.299 0.277 -1.275 0.192 -1.227 c
0.113 -1.172 0.061 -1.087 0.048 -0.991 c
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-0.502 -1.267 -0.657 -1.292 -0.813 -1.293 c
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-1.231 -1.228 -1.322 -1.192 -1.406 -1.142 c
-1.485 -1.082 -1.55 -1.005 -1.594 -0.915 c
-1.642 -0.816 -1.666 -0.707 -1.663 -0.597 c
-1.668 -0.467 -1.638 -0.338 -1.577 -0.223 c
-1.525 -0.13 -1.449 -0.052 -1.358 0.003 c
-1.262 0.059 -1.158 0.099 -1.049 0.12 c
-0.935 0.145 -0.82 0.164 -0.706 0.175 c
-0.614 0.198 -0.52 0.216 -0.425 0.23 c
-0.345 0.236 -0.266 0.25 -0.189 0.271 c
-0.127 0.286 -0.07 0.316 -0.024 0.36 c
0.021 0.41 0.043 0.475 0.038 0.542 c
0.04 0.603 0.022 0.663 -0.014 0.713 c
-0.046 0.757 -0.088 0.792 -0.137 0.816 c
-0.189 0.841 -0.245 0.857 -0.302 0.864 c
-0.359 0.867 -0.416 0.867 -0.473 0.864 c
-0.607 0.87 -0.739 0.836 -0.854 0.768 c
-0.955 0.701 -1.017 0.59 -1.022 0.47 c
-1.57 0.47 l
-1.566 0.61 -1.526 0.747 -1.454 0.867 c
-1.389 0.971 -1.3 1.057 -1.197 1.121 c
-1.091 1.186 -0.975 1.231 -0.854 1.255 c
-0.72 1.281 -0.585 1.293 -0.449 1.293 c
-0.334 1.292 -0.219 1.279 -0.106 1.255 c
0.006 1.232 0.114 1.19 0.213 1.131 c
0.305 1.076 0.384 1 0.442 0.909 c
0.504 0.805 0.534 0.686 0.528 0.566 c
0.528 -0.71 l
h
f
1 0 0 1 0.8915 1.2582 cm
0 0 m
0.411 0 l
0.411 0.73 l
0.96 0.73 l
0.96 0 l
1.454 0 l
1.454 -0.408 l
0.96 -0.408 l
0.96 -1.749 l
0.957 -1.798 0.957 -1.847 0.96 -1.896 c
0.963 -1.933 0.975 -1.97 0.994 -2.002 c
1.013 -2.032 1.041 -2.055 1.073 -2.067 c
1.119 -2.083 1.168 -2.09 1.217 -2.088 c
1.334 -2.088 l
1.372 -2.092 1.412 -2.092 1.45 -2.088 c
1.45 -2.51 l
1.272 -2.53 l
1.094 -2.53 l
0.978 -2.533 0.863 -2.519 0.751 -2.489 c
0.673 -2.468 0.602 -2.426 0.545 -2.369 c
0.494 -2.313 0.46 -2.244 0.446 -2.17 c
0.427 -2.08 0.417 -1.988 0.415 -1.896 c
0.415 -0.422 l
0.003 -0.422 l
0.003 0 l
h
f
1 0 0 1 3.5451 -1.0525 cm
0 0 m
-0.006 0.086 -0.025 0.17 -0.055 0.25 c
-0.083 0.327 -0.124 0.398 -0.178 0.459 c
-0.232 0.519 -0.298 0.568 -0.37 0.603 c
-0.448 0.641 -0.534 0.66 -0.621 0.658 c
-0.71 0.659 -0.799 0.641 -0.881 0.607 c
-0.958 0.575 -1.027 0.527 -1.083 0.466 c
-1.14 0.405 -1.186 0.334 -1.217 0.257 c
-1.249 0.183 -1.269 0.104 -1.275 0.024 c
0 0.024 l
h
-1.275 -0.343 m
-1.275 -0.437 -1.262 -0.53 -1.234 -0.621 c
-1.209 -0.707 -1.167 -0.787 -1.111 -0.857 c
-1.055 -0.926 -0.985 -0.981 -0.905 -1.018 c
-0.812 -1.061 -0.71 -1.082 -0.607 -1.08 c
-0.47 -1.087 -0.335 -1.051 -0.219 -0.977 c
-0.115 -0.9 -0.038 -0.792 0 -0.669 c
0.518 -0.669 l
0.466 -0.921 0.322 -1.145 0.113 -1.296 c
0.009 -1.37 -0.107 -1.426 -0.23 -1.461 c
-0.356 -1.497 -0.486 -1.516 -0.617 -1.515 c
-0.794 -1.519 -0.971 -1.486 -1.135 -1.419 c
-1.28 -1.359 -1.41 -1.268 -1.515 -1.152 c
-1.622 -1.033 -1.703 -0.893 -1.752 -0.741 c
-1.806 -0.57 -1.833 -0.392 -1.831 -0.213 c
-1.831 -0.042 -1.802 0.127 -1.745 0.288 c
-1.692 0.441 -1.611 0.583 -1.505 0.706 c
-1.285 0.961 -0.964 1.104 -0.627 1.097 c
-0.445 1.1 -0.265 1.057 -0.103 0.974 c
0.049 0.895 0.181 0.784 0.285 0.648 c
0.389 0.51 0.465 0.352 0.507 0.185 c
0.554 0.01 0.567 -0.173 0.545 -0.353 c
-1.275 -0.353 l
h
f
1 0 0 1 1.3851 -0.6617 cm
0 0 m
0 -0.137 0.068 -0.266 0.182 -0.343 c
0.297 -0.41 0.429 -0.443 0.562 -0.439 c
0.621 -0.442 0.679 -0.442 0.737 -0.439 c
0.802 -0.415 0.863 -0.383 0.919 -0.343 c
0.973 -0.322 1.022 -0.288 1.059 -0.243 c
1.099 -0.195 1.117 -0.134 1.111 -0.072 c
1.109 -0.007 1.082 0.055 1.035 0.099 c
0.981 0.147 0.919 0.183 0.85 0.206 c
0.766 0.235 0.68 0.257 0.593 0.274 c
0.302 0.336 l
0.202 0.358 0.104 0.385 0.007 0.418 c
-0.088 0.443 -0.178 0.482 -0.261 0.535 c
-0.337 0.589 -0.399 0.661 -0.442 0.744 c
-0.49 0.842 -0.513 0.95 -0.511 1.059 c
-0.516 1.181 -0.481 1.302 -0.411 1.402 c
-0.345 1.493 -0.26 1.568 -0.161 1.622 c
-0.054 1.679 0.062 1.719 0.182 1.738 c
0.295 1.76 0.409 1.771 0.525 1.773 c
0.648 1.773 0.771 1.759 0.891 1.731 c
1.003 1.706 1.11 1.662 1.207 1.601 c
1.305 1.544 1.389 1.465 1.454 1.371 c
1.517 1.267 1.557 1.15 1.57 1.029 c
1.008 1.029 l
0.995 1.141 0.927 1.24 0.826 1.293 c
0.724 1.34 0.613 1.363 0.501 1.361 c
0.363 1.361 l
0.313 1.356 0.264 1.344 0.216 1.327 c
0.172 1.311 0.132 1.285 0.099 1.251 c
0.067 1.216 0.05 1.169 0.051 1.121 c
0.049 1.059 0.074 0.998 0.12 0.957 c
0.173 0.911 0.235 0.876 0.302 0.854 c
0.386 0.824 0.471 0.802 0.559 0.785 c
0.857 0.686 l
0.956 0.663 1.053 0.635 1.149 0.603 c
1.24 0.573 1.327 0.529 1.406 0.473 c
1.481 0.419 1.543 0.349 1.587 0.267 c
1.636 0.172 1.66 0.066 1.656 -0.041 c
1.659 -0.173 1.625 -0.302 1.557 -0.415 c
1.49 -0.517 1.401 -0.603 1.296 -0.665 c
1.19 -0.73 1.074 -0.777 0.953 -0.806 c
0.826 -0.835 0.696 -0.849 0.566 -0.85 c
0.419 -0.852 0.273 -0.835 0.13 -0.799 c
0.007 -0.767 -0.109 -0.712 -0.213 -0.638 c
-0.309 -0.567 -0.387 -0.476 -0.442 -0.37 c
-0.505 -0.256 -0.542 -0.13 -0.549 0 c
h
f
1 0 0 1 -10.7691 13.2171 cm
0.66701 0.17599 0.11 scn
0 0 m
7.303 4.869 l
7.303 10.707 l
0 10.707 l
h
f
1 0 0 1 7.3029 0 cm
0.804 0.21201 0.259 scn
0 0 m
-7.303 4.869 l
-7.303 10.707 l
0 10.707 l
h
f
1 0 0 1 -3.6515 -2.16 cm
0.435 0.68201 0.77299 scn
0 0 m
-3.361 0 -6.086 2.725 -6.086 6.086 c
-6.086 9.447 -3.361 12.171 0 12.171 c
3.361 12.171 6.086 9.447 6.086 6.086 c
6.086 2.725 3.361 0 0 0 c
0 14.143 m
-4.45 14.143 -8.057 10.536 -8.057 6.086 c
-8.057 1.636 -4.45 -1.971 0 -1.971 c
4.45 -1.971 8.057 1.636 8.057 6.086 c
8.057 10.536 4.45 14.143 0 14.143 c
f
1 0 0 1 4.4572 1.9715 cm
0.937 0.77299 0.25101 scn
0 0 m
-2.289 -2.456 -6.136 -2.59 -8.592 -0.301 c
-10.419 1.403 -11.018 4.053 -10.101 6.377 c
-11.787 7.443 l
-13.654 3.408 -11.895 -1.376 -7.86 -3.242 c
-4.546 -4.775 -0.617 -3.886 1.714 -1.077 c
h
f
EMC
Q
BT
/T1_2 1 Tf
9.6 0 0 9.6 54 381.4 Tm
(INTRODUCT) Tj
ET
BT
/Span <<
/ActualText (i)
>> BDC
/T1_2 1 Tf
9.6 0 0 9.6 100.2336 381.4 Tm
(I) Tj
EMC
ET
BT
/T1_2 1 Tf
9.6 0 0 9.6 102.72 381.4 Tm
(ON) Tj
/T1_3 1 Tf
0.21001 Tw
10 0 0 10 54 369.7 Tm
[ (Acute m) 30 (y) 40 (eloid leuk) 30 (emia \050AML\051 is a g) -30 (r) 30 (oup of genetically ) ] TJ
0.325 Tw
0 -1.17 TD
[ (di) 20 (v) 40 (er) -20 (se ) 0.6 (and ) 0.5 (highly ) 0.6 (agg) -30 (r) 20 (essi) 20 (v) 40 (e ) 0.6 (hematolo) 20 (g) -30 (ical ) 0.6 (malignancies ) ] TJ
0.073 Tw
T*
[ (character) -44.9 (ized b) 25 (y the accum) 15.1 (ulation of immatur) 20 (e b) 15 (lasts\056) 100 ( ) 80.3 (AML ) ] TJ
-0.056 Tw
T*
[ (r) 20 (epr) 20 (esents the most common for) -45 (m of acute leuk) 30.1 (emia in adults ) ] TJ
0.06 Tw
T*
[ (and accounts for most leuk) 30.1 (emia\055r) 20 (elated deaths \050Siegel et al\056\054) 100 ( ) ] TJ
0 Tw
T*
[ (2013\073) 100 ( D\366hner et al\056\054) 100.1 ( 2015\051\056) ] TJ
0.08501 Tw
2.16 -1.17 Td
[ (In r) 20 (ecent y) 40 (ear) -19.9 (s\054) 100 ( genetic and molecular aber) -40 (rations un) ] TJ
0 Tw
(\055) Tj
0.07001 Tw
-2.16 -1.17 Td
[ (derlying ) 80.1 (AML patho) 20.1 (genesis ha) 30 (v) 40 (e been identi\037ed\056) 100 ( ) 80.1 (A \037r) -20 (st ge) ] TJ
0 Tw
[ 0.1 (\055) ] TJ
0.14999 Tw
T*
[ (netic alteration occur) -19.9 (s in a hematopoietic stem\057pr) 30 (o) 20 (genitor ) ] TJ
-0.034 Tw
T*
[ (cell \050HSPC\051\054) 100 ( initiating clonal expansion\056) 100 ( Subsequently) 120.1 (\054) 100 ( within ) ] TJ
0.16499 Tw
T*
[ (this expanding clone) 30 (\054) 100 ( additional cooperating m) 15 (utations ar) 20 (e ) ] TJ
0.064 Tw
T*
[ (acquir) 20 (ed\054) 100 ( r) 20 (esulting in aber) -39.9 (rant cell g) -30 (r) 30 (o) 40 (wth and a di\036er) 20 (entia) ] TJ
0 Tw
(\055) Tj
0.02901 Tw
T*
[ (tion ) 0.6 (b) 14.9 (lock ) 0.5 (\050J) 30 (an ) 0.6 (et ) 0.5 (al\056\054) 100 ( ) 0.5 (2012\073) 100.1 ( ) 0.5 (Cor) 20 (ces\055Zimmer) -44.9 (man ) 0.5 (et ) 0.6 (al\056\054) 100 ( ) 0.5 (2014\073) 100.1 ( ) ] TJ
0.155 Tw
T*
[ (Shlush et al\056\054) 100.1 ( 2014\073) 100 ( ) 174.6 (V) 125 (asanthakumar and Godle) 20 (y) 120 (\054) 100 ( 2014\051\056) 100.1 ( ) 124.6 (The ) ] TJ
0.105 Tw
T*
[ (impr) 30 (o) 40 (v) 40 (ed under) -19.9 (standing of disease mechanisms has allo) 40.1 (w) 40 (ed ) ] TJ
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0.03999 Tw
25.8 18.72 Td
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0 Tw
[ -0.1 (\055) ] TJ
-0.02299 Tw
T*
[ (tarabine ) 0.5 (with ) 0.5 (an anthracycline) 30.1 (\056) 100 ( ) 0.5 (Ho) 40 (w) 40 (e) 20 (v) 40 (er) 40 (\054) 100 ( ) 0.5 (the character) -44.9 (ization ) ] TJ
0.08299 Tw
T*
[ (of ) 0.5 (molecular ) 0.5 (abnor) -45 (malities ) 0.6 (in ) 80.5 (AML ) 0.6 (has ) 0.5 (led ) 0.5 (to ) 0.6 (the ) 0.5 (de) 20 (v) 40 (elop) ] TJ
0 Tw
[ -0.1 (\055) ] TJ
0.02 Tw
T*
[ (ment of no) 40 (v) 40 (el targeted agents\054) 100 ( including FL) 100 (T3\054) 100 ( IDH1\0572\054) 100.1 ( and ) ] TJ
0 Tw
T*
[ (KIT inhibitor) -19.9 (s \050D\366hner et al\056\054) 100.1 ( 2015\051\056) ] TJ
0.02 Tc
0.114 Tw
2.16 -1.17 Td
[ (AML is hierar) 20 (chically organized and maintained b) 25 (y) 20 ( ) ] TJ
0.20799 Tw
-2.16 -1.17 Td
[ (self\055r) 20 (ene) 20 (wing leuk) 30.1 (emia stem cells \050LSCs\051 that sustain a) 20 ( ) ] TJ
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T*
[ (pool of disease\055inducing cells \050Re) 20 (y) 30 (a et al\056\054) 100 ( 2001\073) 100 ( Huntly) 20 ( ) ] TJ
0.02299 Tw
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[ (and Gilliland\054) 100 ( 2005\073) 100.1 ( Hor) -25 (ton and Huntly) 120.1 (\054) 100 ( 2012\051\056) 100 ( LSCs ma) 30 (y) 20 ( ) ] TJ
0.245 Tw
T*
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0.067 Tw
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T*
[ (this balance to) 40 (w) 30 (ar) 20 (d symmetr) -45 (ic self\055r) 20 (ene) 20 (w) 30 (al will lead to) 20 ( ) ] TJ
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[ (an accum) 15.1 (ulation of undi\036er) 20 (entiated malignant cells with) 20 ( ) ] TJ
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[ (stem cell character) -45 (istics \050Kr) 20 (eso and Dick\054) 99.9 ( 2014\073) 100 ( Bajaj et) 20 ( ) ] TJ
-0.01199 Tw
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0.009 Tw
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0.121 Tw
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[ (b) 15 (last phase wher) 20 (e the fraction of symmetr) -45 (ically di) 20 (viding) 20.1 ( ) ] TJ
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0.08099 Tw
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[ (et al\056\054) 100 ( 2015\051\056) 100 ( Concor) 20 (dantly) 120 (\054) 100 ( high LSC n) 15 (umber) -20 (s as w) 40 (ell as) 20 ( ) ] TJ
0.08501 Tw
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0.07001 Tw
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(\055) Tj
-0.022 Tw
-51.412 -1.25 Td
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EMC
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BT
/T1_2 1 Tf
9.6 0 0 9.6 126.8736 520.9 Tm
(F superfamily ligand\226receptor pair ) Tj
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/Span <<
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/T1_2 1 Tf
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EMC
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BT
/T1_2 1 Tf
9.6 0 0 9.6 278.5536 520.9 Tm
[ (7) 37 (0\057) ] TJ
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BT
/Span <<
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>> BDC
/T1_2 1 Tf
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(CD) Tj
EMC
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BT
/T1_2 1 Tf
9.6 0 0 9.6 302.928 520.9 Tm
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/Span <<
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/T1_2 1 Tf
0.05901 Tw
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(CD) Tj
EMC
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BT
/T1_2 1 Tf
9.6 0 0 9.6 65.0304 508.9 Tm
[ (7) 37 (0\057) ] TJ
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/Span <<
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>> BDC
/T1_2 1 Tf
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(CD) Tj
EMC
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BT
/T1_2 1 Tf
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>> BDC
/T1_2 1 Tf
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(CD) Tj
EMC
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BT
/T1_2 1 Tf
9.6 0 0 9.6 264.4512 496.9 Tm
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(CD) Tj
EMC
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/T1_2 1 Tf
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(CD) Tj
EMC
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/T1_2 1 Tf
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0.03999 Tw
-51.412 -1.25 Td
(cantly elevated in the sera of newly diagnosed AML patients and is a strong independent negative prognostic biomarker for ) Tj
0.075 Tw
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(overall survival\056 Blocking the ) Tj
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/Span <<
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(CD) Tj
EMC
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/T1_2 1 Tf
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[ (7) 36.9 (0\057) ] TJ
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>> BDC
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(CD) Tj
EMC
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BT
/T1_2 1 Tf
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-0.04401 Tw
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>> BDC
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(CD) Tj
EMC
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/T1_2 1 Tf
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[ (7) 37 (0 nor ) ] TJ
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/Span <<
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>> BDC
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(CD) Tj
EMC
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BT
/T1_2 1 Tf
9.6 0 0 9.6 541.27584 448.9 Tm
(27 ) Tj
-0.05901 Tw
-50.7579 -1.25 Td
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/Span <<
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>> BDC
/T1_2 1 Tf
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(T) Tj
EMC
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BT
/T1_2 1 Tf
9.6 0 0 9.6 253.1808 436.9 Tm
(herefore\054 targeting ) Tj
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BT
/Span <<
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>> BDC
/T1_2 1 Tf
9.6 0 0 9.6 330.0864 436.9 Tm
(CD) Tj
EMC
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BT
/T1_2 1 Tf
9.6 0 0 9.6 341.1168 436.9 Tm
[ (7) 37 (0\057) ] TJ
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/Span <<
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>> BDC
/T1_2 1 Tf
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(CD) Tj
EMC
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BT
/T1_2 1 Tf
9.6 0 0 9.6 365.4912 436.9 Tm
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EMC
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/T1_3 1 Tf
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[ (Correspondence to Adrian F) 56 (\056 Ochsenbein\072 adrian\056ochsenbein\100insel\056ch) ] TJ
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(Abbreviations used\072 AML\054 acute myeloid leukemia\073 APC\054 allophycocyanin\073 CML\054 ) Tj
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0.00999 Tw
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