Diagnostik und Therapie myelodysplastischer Syndrome

Bonadies, Nicolas; Rüfer, Axel (2016). Diagnostik und Therapie myelodysplastischer Syndrome. Schweizer Zeitschrift für Onkologie(4), pp. 28-36. Rosenfluh Publikationen AG

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Diagnosis and treatment of myelodysplastic syndromes
The myelodysplastic syndromes (MDS) are heterogeneous clonal disorders of
the hematopoietic stem cells and affect mainly elderly people from the 7th decade
of life. Management of MDS patients is challenging due to the broad spectrum
of presentations and courses of the disease, varying from chronic cytopenia
to rapid progression towards acute myeloid leukaemia (AML). The incidence
and prevalence of MDS is expected to increase due to ageing of the population.
Therefore, MDS is assumed to become one of the most important haematologic
malignancies with an emerging impact on future healthcare costs. The only curative
treatment is an allogeneic hematopoietic stem cell transplantation for
which only a minority of patients is eligible. This review shall provide an update
for practicing hemato-oncologists on the current understanding of pathophysiology
as well as the recommendations for diagnosis and treatment of this
emerging disease.

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