Bowen disease of the nail unit: a retrospective study of 12 cases and their association with human papillomaviruses.

Perruchoud, Delphine Lydie; Varonier, C; Haneke, Eckart; Hunger, Robert; Beltraminelli, Helmut; Borradori, Luca; Ehnis Pérez, A (2016). Bowen disease of the nail unit: a retrospective study of 12 cases and their association with human papillomaviruses. Journal of the European Academy of Dermatology and Venereology, 30(9), pp. 1503-1506. Blackwell 10.1111/jdv.13654

[img] Text
jdv13654.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (212kB) | Request a copy

BACKGROUND Bowen disease is the most frequent nail malignancy, usually seen as a verrucous plaque of the nail in men. OBJECTIVE To characterize the affected patient population, the clinical manifestations, the diagnostic delay and diagnostic steps, and presence of human papilloma virus (HPV) infection. METHODS We retrospectively evaluated all cases of Bowen disease of the nail unit over a period of 9 years. Data were obtained from our electronic database. Human papilloma virus genotype was assessed in biopsy specimens by polymerase chain reaction (PCR) sequencing. RESULTS We identified 12 cases of Bowen disease of the nail unit in 10 patients. Mean age at onset was 52 years, with a male predominance of 90%. The thumb and middle finger were the most frequently affected (66%). Fifty percent of the lesions presented as periungual and subungual verrucous tumours. Patients sought medical evaluation after a mean delay of 5.7 years; histopathological diagnosis was made after a mean delay of 3.2 years. HPV infection was identified in 75% of the cases. CONCLUSIONS Any recently appeared verrucous lesion of the nail unit in men above the age of 40 years should raise the suspicion of Bowen disease and lead to further histopathological diagnostic procedures.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology

UniBE Contributor:

Perruchoud, Delphine Lydie; Haneke, Eckart; Hunger, Robert; Beltraminelli, Helmut and Borradori, Luca

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0926-9959

Publisher:

Blackwell

Language:

English

Submitter:

Sandra Nyffenegger

Date Deposited:

20 Feb 2017 11:20

Last Modified:

20 Feb 2017 11:20

Publisher DOI:

10.1111/jdv.13654

PubMed ID:

27405962

BORIS DOI:

10.7892/boris.93902

URI:

https://boris.unibe.ch/id/eprint/93902

Actions (login required)

Edit item Edit item
Provide Feedback