TH9 cells in skin disorders

Clark, Rachael A; Schlapbach, Christoph (2017). TH9 cells in skin disorders. Seminars in immunopathology, 39(1), pp. 47-54. Springer 10.1007/s00281-016-0607-8

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Interleukin 9 secreting TH9 cells have been proposed as the latest addition to the family of T helper cell subsets. While a growing body of evidence from animal models points to important roles for these cells in allergic inflammation of the lung, autoinflammation of the gastrointestinal tract, and tumor immunity, their role in skin immunity and skin immunopathology remains poorly defined. Interestingly, studies of T helper cells from healthy humans suggest that TH9 cells are predominantly skin-homing and skin-resident and that they are involved in protection against extracellular pathogens. Thus, TH9 cells have entered the stage as potential mediators of cutaneous pathology. However, under which conditions and by which mechanisms these cells contribute to skin immunity and disease still has to be investigated. Here, we review our current understanding of TH9 cells as skin-tropic T helper cells and their involvement in skin pathology. Further, we discuss open questions with regard to the intricate nature of interleukin 9 producing T helper cells.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology

UniBE Contributor:

Schlapbach, Christoph

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1863-2297

Publisher:

Springer

Language:

English

Submitter:

Sandra Nyffenegger

Date Deposited:

16 Mar 2017 10:51

Last Modified:

16 Mar 2017 10:51

Publisher DOI:

10.1007/s00281-016-0607-8

PubMed ID:

27896634

Uncontrolled Keywords:

Allergic contact dermatitis; Atopic dermatitis; Candida albicans; Cutaneous; Cutaneous T cell lymphoma; IL-9; Inflammation; Interleukin 9; Psoriasis; Skin; Skin homing; Skin resident; T helper cell subsets; T helper cells; T helper type 9 cells; Th9 cells

BORIS DOI:

10.7892/boris.93914

URI:

https://boris.unibe.ch/id/eprint/93914

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