Treatment of sporadic port-wine stains: a retrospective review of 17 cases consecutively treated by pulsed sequential dual wavelength 595 and 1064 nm laser.

Perruchoud, Delphine Lydie; Cazzaniga, Simone; Heidemeyer, Kristine; Weber, B; Dietrich, Nathalie; Borradori, Luca; Adatto, Maurice Alfred (2017). Treatment of sporadic port-wine stains: a retrospective review of 17 cases consecutively treated by pulsed sequential dual wavelength 595 and 1064 nm laser. Journal of the European Academy of Dermatology and Venereology, 31(3), pp. 557-563. Wiley 10.1111/jdv.13975

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BACKGROUND Port-wine stains (PWS) are relatively common and often cause cosmetic and psychological concerns. The pulsed dye laser is currently the treatment of choice for PWS. OBJECTIVE To assess the effectiveness of the pulsed sequential dual wavelength 595 and 1064 nm laser as first-line treatment for PWS and to identify prognostic factors for treatment outcome in a retrospective series of 17 consecutive previously untreated patients. METHODS The response to treatment was evaluated 2 months after treatment utilizing comparative photographs and a standard physician global assessment (PGA) grading system. Furthermore, measurement of the normalized erythema index (NEI) reduction (ΔNEI%) was carried out using an image analysis system. The subjective improvement was assessed using a patient's satisfaction questionnaire. Multiple linear regression models were finally used to identify factors associated with ΔNEI% and patients' satisfaction. RESULTS Seventeen patients, with PWS, including 12 children were included. The average PGA assessment was 2.5 ± 1.3 corresponding to an amelioration of 50% with a high intraclass correlation coefficient among the experts. The before-after NEI showed a statistically significant mean reduction of 3.5 ± 2.6 units, corresponding to a relative reduction of 31%. Questionnaires showed that the satisfaction was very good with an average score of 6.1 points on a scale ranging from -10 to 10 points. Multiple regression analysis revealed that location in the frontotemporal area was associated with a significant reduction in ΔNEI% (38.4%; 95% CI 4.3, 72.6). Presence of PWS on the neck was associated with a lower patient satisfaction (-3.7 points; 95% CI -6.5, -0.9). There were no significant side-effects, except for transient discomfort and purpura. CONCLUSIONS Based on the results obtained in the largest reported series so far, the pulsed sequential dual wavelength 595 and 1064 nm laser represents an effective and safe first-line therapeutic option for the treatment of PWS.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology

UniBE Contributor:

Perruchoud, Delphine Lydie; Cazzaniga, Simone; Heidemeyer, Kristine; Dietrich, Nathalie; Borradori, Luca and Adatto, Maurice Alfred

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0926-9959

Publisher:

Wiley

Language:

English

Submitter:

Sandra Nyffenegger

Date Deposited:

14 Feb 2017 15:43

Last Modified:

16 Mar 2017 01:31

Publisher DOI:

10.1111/jdv.13975

PubMed ID:

27658196

BORIS DOI:

10.7892/boris.93919

URI:

https://boris.unibe.ch/id/eprint/93919

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