Nicolau syndrome due to hyaluronic acid injections.

Andre, Pierre; Haneke, Eckart (2016). Nicolau syndrome due to hyaluronic acid injections. Journal of cosmetic and laser therapy, 18(4), pp. 239-244. Informa Healthcare 10.3109/14764172.2016.1157260

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Six cases of vascular compromise after hyaluronic injection are reported. Clinical symptoms realized a Nicolau syndrome, which is characterized by immediate pain, livedoid pattern and a few days later by the appearance of scabs and skin necrosis. This type of complication is rare, but may be dramatic and injectors must be aware of that. A thorough knowledge of facial anatomy is mandatory to avoid the risky facial areas. The use of a flexible cannula instead of a sharp needle has much less risk of hurting vessels and must be preferred. The support of the patient is discussed and a treatment protocol is proposed.

Item Type:

Journal Article (Further Contribution)


04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology

UniBE Contributor:

Haneke, Eckart


600 Technology > 610 Medicine & health




Informa Healthcare




Andrea Studer-Gauch

Date Deposited:

28 Feb 2017 09:25

Last Modified:

09 Jul 2021 09:40

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Filler complications; hyaluronic acid; hyaluronidase; intra-arterial injection; nicolau syndrome


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