Tenascin-C at a glance.

Midwood, Kim S; Chiquet, Matthias; Tucker, Richard P; Orend, Gertraud (2016). Tenascin-C at a glance. Journal of cell science, 129(23), pp. 4321-4327. Company of Biologists Limited 10.1242/jcs.190546

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Tenascin-C (TNC) is a hexameric, multimodular extracellular matrix protein with several molecular forms that are created through alternative splicing and protein modifications. It is highly conserved amongst vertebrates, and molecular phylogeny indicates that it evolved before fibronectin. Tenascin-C has many extracellular binding partners, including matrix components, soluble factors and pathogens; it also influences cell phenotype directly through interactions with cell surface receptors. Tenascin-C protein synthesis is tightly regulated, with widespread protein distribution in embryonic tissues, but restricted distribution of tenascin-C in adult tissues. Tenascin-C is also expressed de novo during wound healing or in pathological conditions, including chronic inflammation and cancer. First described as a modulator of cell adhesion, tenascin-C also directs a plethora of cell signaling and gene expression programs by shaping mechanical and biochemical cues within the cellular microenvironment. Exploitment of the pathological expression and function of tenascin-C is emerging as a promising strategy to develop new diagnostic, therapeutic and bioengineering tools. In this Cell Science at a Glance article and the accompanying poster we provide a succinct and comprehensive overview of the structural and functional features of tenascin-C and its potential roles in developing embryos and under pathological conditions.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > Department of Orthodontics
04 Faculty of Medicine > School of Dental Medicine > School of Dental Medicine, Orthodontic Research

UniBE Contributor:

Chiquet, Matthias

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0021-9533

Publisher:

Company of Biologists Limited

Language:

English

Submitter:

Eveline Carmen Schuler

Date Deposited:

16 Feb 2017 10:31

Last Modified:

04 Oct 2017 17:16

Publisher DOI:

10.1242/jcs.190546

PubMed ID:

27875272

Uncontrolled Keywords:

Cancer, Chronic Inflammation, Extracellular matrix, Matricellular molecule, TNC, Tenascin-C, Tissue repair

BORIS DOI:

10.7892/boris.93948

URI:

https://boris.unibe.ch/id/eprint/93948

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